Reference : MOISTURE CONTENT DETERMINATION OF FREEZE-DRIED PRODUCTS BY NEAR-INFRARED SPECTROSCOPY...
Scientific congresses and symposiums : Poster
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/195256
MOISTURE CONTENT DETERMINATION OF FREEZE-DRIED PRODUCTS BY NEAR-INFRARED SPECTROSCOPY: A CASE STUDY FOR UNIVERSAL REGRESSION MODEL
English
Clavaud, Matthieu mailto [Université de Liège - ULiège > > > Form. doct. sc. biomed. & pharma. (paysage)]
Roggo, Yves []
Degardin, Klara []
Hubert, Philippe mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Ziemons, Eric mailto [Université de Liège > Département de pharmacie > Département de pharmacie >]
6-Jun-2016
Poster
Yes
No
International
XVI Chemometrics in Analytical Chemistry
6-10 june 2016
CAC Permanent Committee
Barcelona
Spain
[en] Moisture content determination ; Freeze-dried products ; Near infrared spectroscopy ; Chemometrics ; Pharmaceutical field
[en] Karl Fischer titration is the reference method for moisture content determination in the pharmaceutical industry. Near-infrared spectroscopy is considered the most suitable alternative technique. Indeed, NIRS is a safe and fast method which does not require sample preparation. Nevertheless, the development and validation phases are time-consuming. In addition, the NIRS methods presented so far were mostly product specific. The main objective of this study is to highlight that an universal calibration model can be validated for several freeze-dried products in order to speed up the validation time. This objective was led in two steps. A universal model was first evaluated. A calibration set and a validation set were built up with three freeze-dried products. An antibody drug conjugate, a large molecule and a small molecule all packed in sealed vials were used to introduce more variability. Regression methods were then compared in order to optimize the prediction values.
Centre Interfacultaire de Recherche du Médicament - CIRM
Researchers ; Professionals
http://hdl.handle.net/2268/195256

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
MClavaud_CAC_2016_Abstract and poster.pdfAuthor postprint590.64 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.