Article (Scientific journals)
A proteome-scale map of the human interactome network.
Rolland, Thomas; Tasan, Murat; Charloteaux, Benoît et al.
2014In Cell, 159 (5), p. 1212-26
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Keywords :
Animals; Databases, Protein; Genome-Wide Association Study; Humans; Mice; Neoplasms/metabolism; Protein Interaction Maps; Proteome/metabolism
Abstract :
[en] Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a broader" human interactome network than currently appreciated. The map also uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots" of the genomic revolution."
Disciplines :
Genetics & genetic processes
Author, co-author :
Rolland, Thomas 
Tasan, Murat 
Charloteaux, Benoît  ;  Université de Liège > Département de productions animales > GIGA-R : Génomique animale
Pevzner, Samuel J. 
Zhong, Quan 
Sahni, Nidhi 
Yi, Song 
Lemmens, Irma
Fontanillo, Celia
Mosca, Roberto
Kamburov, Atanas
Ghiassian, Susan D.
Yang, Xinping
Ghamsari, Lila
Balcha, Dawit
Begg, Bridget E.
Braun, Pascal
Brehme, Marc
Broly, Martin P.
Carvunis, Anne-Ruxandra
Convery-Zupan, Dan
Corominas, Roser
Coulombe-Huntington, Jasmin
Dann, Elizabeth
Dreze, Matija
Dricot, Amelie
Fan, Changyu
Franzosa, Eric
Gebreab, Fana
Gutierrez, Bryan J.
Hardy, Madeleine F.
Jin, Mike
Kang, Shuli
Kiros, Ruth
Lin, Guan Ning
Luck, Katja
MacWilliams, Andrew
Menche, Jorg
Murray, Ryan R.
Palagi, Alexandre
Poulin, Matthew M.
Rambout, Xavier ;  Université de Liège - ULiège
Rasla, John
Reichert, Patrick
Romero, Viviana
Ruyssinck, Elien
Sahalie, Julie M.
Scholz, Annemarie
Shah, Akash A.
Sharma, Amitabh
Shen, Yun
Spirohn, Kerstin
Tam, Stanley
Tejeda, Alexander O.
Trigg, Shelly A.
Twizere, Jean-Claude  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Vega, Kerwin
Walsh, Jennifer
Cusick, Michael E.
Xia, Yu
Barabasi, Albert-Laszlo
Iakoucheva, Lilia M.
Aloy, Patrick
De Las Rivas, Javier
Tavernier, Jan
Calderwood, Michael A.
Hill, David E.
Hao, Tong
Roth, Frederick P.
Vidal, Marc
More authors (60 more) Less
 These authors have contributed equally to this work.
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Title :
A proteome-scale map of the human interactome network.
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Cell Press, United States - Massachusetts
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Peer Reviewed verified by ORBi
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since 06 January 2016


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