Reference : A proteome-scale map of the human interactome network.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/190434
A proteome-scale map of the human interactome network.
English
Rolland, Thomas [> >]
Tasan, Murat [> >]
Charloteaux, Benoît mailto [Université de Liège > Département de productions animales > GIGA-R : Génomique animale >]
Pevzner, Samuel J. [> >]
Zhong, Quan [> >]
Sahni, Nidhi [> >]
Yi, Song [> >]
Lemmens, Irma [> >]
Fontanillo, Celia [> >]
Mosca, Roberto [> >]
Kamburov, Atanas [> >]
Ghiassian, Susan D. [> >]
Yang, Xinping [> >]
Ghamsari, Lila [> >]
Balcha, Dawit [> >]
Begg, Bridget E. [> >]
Braun, Pascal [> >]
Brehme, Marc [> >]
Broly, Martin P. [> >]
Carvunis, Anne-Ruxandra [> >]
Convery-Zupan, Dan [> >]
Corominas, Roser [> >]
Coulombe-Huntington, Jasmin [> >]
Dann, Elizabeth [> >]
Dreze, Matija [> >]
Dricot, Amelie [> >]
Fan, Changyu [> >]
Franzosa, Eric [> >]
Gebreab, Fana [> >]
Gutierrez, Bryan J. [> >]
Hardy, Madeleine F. [> >]
Jin, Mike [> >]
Kang, Shuli [> >]
Kiros, Ruth [> >]
Lin, Guan Ning [> >]
Luck, Katja [> >]
MacWilliams, Andrew [> >]
Menche, Jorg [> >]
Murray, Ryan R. [> >]
Palagi, Alexandre [> >]
Poulin, Matthew M. [> >]
Rambout, Xavier [Université de Liège - ULiège > > >]
Rasla, John [> >]
Reichert, Patrick [> >]
Romero, Viviana [> >]
Ruyssinck, Elien [> >]
Sahalie, Julie M. [> >]
Scholz, Annemarie [> >]
Shah, Akash A. [> >]
Sharma, Amitabh [> >]
Shen, Yun [> >]
Spirohn, Kerstin [> >]
Tam, Stanley [> >]
Tejeda, Alexander O. [> >]
Trigg, Shelly A. [> >]
Twizere, Jean-Claude mailto [Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc. >]
Vega, Kerwin [> >]
Walsh, Jennifer [> >]
Cusick, Michael E. [> >]
Xia, Yu [> >]
Barabasi, Albert-Laszlo [> >]
Iakoucheva, Lilia M. [> >]
Aloy, Patrick [> >]
De Las Rivas, Javier [> >]
Tavernier, Jan [> >]
Calderwood, Michael A. [> >]
Hill, David E. [> >]
Hao, Tong [> >]
Roth, Frederick P. [> >]
Vidal, Marc [> >]
2014
Cell
159
5
1212-26
Yes (verified by ORBi)
International
0092-8674
1097-4172
United States
[en] Animals ; Databases, Protein ; Genome-Wide Association Study ; Humans ; Mice ; Neoplasms/metabolism ; Protein Interaction Maps ; Proteome/metabolism
[en] Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a broader" human interactome network than currently appreciated. The map also uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots" of the genomic revolution."
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/190434

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