Article (Scientific journals)
New biomarkers for primary mitral regurgitation.
Deroyer, Céline; Magne, Julien; Moonen, Marie et al.
2015In Clinical Proteomics, 12, p. 25
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Keywords :
Autophagy; Biomarkers; Lipid metabolism; Mitral regurgitation
Abstract :
[en] BACKGROUND: Mitral regurgitation is a frequent valvular heart disease affecting around 2.5 % of the population with prevalence directly related to aging. Degeneration of mitral valve is broadly considered as a passive ongoing pathophysiological process and little is known about its physiological deregulation. The purpose of this study was to highlight new biomarkers of mitral regurgitation in order to decipher the underlying pathological mechanism as well as to allow the diagnosis and the monitoring of the disease. RESULTS: Modulation of various blood proteins expression was examined in patients suffering from different grades of mitral regurgitation (mild, moderate and severe) compared to healthy controls. To this end, several routine clinical assays and the multi analyte profile technology targeting 184 proteins were used. High-density lipoprotein, apolipoprotein-A1, haptoglobin and haptoglobin-alpha2 chain levels significantly decreased proportionally to the degree of mitral regurgitation when compared to controls. High-density lipoprotein and apolipoprotein-A1 levels were associated with effective regurgitant orifice area and regurgitant volume. Apolipoprotein-A1 was an independent predictor of severe mitral regurgitation. Moreover, with ordinal logistic regression, apolipoprotein-A1 remained the only independent factor associated with mitral regurgitation. In addition, myxomatous mitral valves were studied by immunocytochemistry. We observed an increase of LC3, the marker of autophagy, in myxomatous mitral valves compared with healthy mitral valves. CONCLUSION: These potential biomarkers of mitral regurgitation highlighted different cellular processes that could be modified in myxomatous degenerescence: reverse cholesterol transport, antioxidant properties and autophagy.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Deroyer, Céline  
Magne, Julien
Moonen, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Le Goff, Caroline  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Dupont, Laura 
Hulin, Alexia 
Radermecker, Marc ;  Université de Liège > Département des sciences biomédicales et précliniques > Anatomie humaine
Colige, Alain ;  Université de Liège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
Cavalier, Etienne  ;  Université de Liège > Département de pharmacie > Chimie médicale
Kolh, Philippe  ;  Université de Liège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.
Pierard, Luc ;  Université de Liège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Merville, Marie-Paule ;  Université de Liège > Département de pharmacie > Chimie médicale
Fillet, Marianne ;  Université de Liège > Département de pharmacie > Analyse des médicaments
More authors (4 more) Less
Language :
English
Title :
New biomarkers for primary mitral regurgitation.
Publication date :
2015
Journal title :
Clinical Proteomics
ISSN :
1542-6416
eISSN :
1559-0275
Publisher :
BioMed Central, United Kingdom
Volume :
12
Pages :
25
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 January 2016

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