Article (Scientific journals)
Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
Vanvinckenroye, Amaury; Vandewalle, Gilles; Phillips, Christophe et al.
2015In Neural Plasticity
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Keywords :
Sleep; Neuronal dynamics; modelling
Abstract :
[en] Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscillations shape cortical function in time and space. On a much longer time scale, brain function also depends on prior sleep-wake history and circadian processes. However,much remains to be established on how the brain operates at the neuronal level in humans during sleep and wakefulness. A key limitation of human neuroscience is the difficulty in isolating neuronal excitation/inhibition drive in vivo. Therefore, computational models are noninvasive approaches of choice to indirectly access hidden neuronal states. In this review, we present a physiologically driven in silico approach, Dynamic Causal Modelling (DCM), as a means to comprehend brain function under different experimental paradigms. Importantly, DCM has allowed for the understanding of how brain dynamics underscore brain plasticity, cognition, and different states of consciousness. In a broader perspective, noninvasive computational approaches, such as DCM, may help to puzzle out the spatial and temporal dynamics of human brain function at different behavioural states.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Human health sciences: Multidisciplinary, general & others
Neurology
Author, co-author :
Vanvinckenroye, Amaury ;  Université de Liège - ULiège > 2e an. master ingé. civ. biomédical, fin. appr.
Vandewalle, Gilles  ;  Université de Liège > Centre de recherches du cyclotron
Phillips, Christophe  ;  Université de Liège > Centre de recherches du cyclotron
Chellappa, Sarah Laxhmi ;  Université de Liège > Centre de recherches du cyclotron
Language :
English
Title :
Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
Publication date :
October 2015
Journal title :
Neural Plasticity
ISSN :
2090-5904
eISSN :
1687-5443
Publisher :
Hindawi Publishing Corporation, New York, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 November 2015

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