Article (Scientific journals)
Earlier onset of delta-retrovirus-induced leukemia after splenectomy.
Florins, ARNAUD-FRANCOIS; Reichert, Michal; Asquith, Becca et al.
2009In PLoS ONE, 4 (9), p. 6943
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Abstract :
[en] Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (<5%) of delta-retrovirus infected hosts will develop either lymphoproliferative or neurodegenerative diseases after long latency periods. In fact, the host immune response is believed to tightly control viral replication but this assumption has not been definitely proven in vivo. Here, we provide direct experimental evidence demonstrating that integrity of the spleen is required to control pathogenesis. In the BLV model, we show that asplenia decreases efficiency of the immune response and induces an imbalance in cell dynamics resulting in accelerated onset of leukemia. These observations enlighten a potential threat in splenectomized HTLV-1 carriers and justify a regular preventive evaluation.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Florins, ARNAUD-FRANCOIS ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Reichert, Michal
Asquith, Becca
Bouzar, Amel ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Jean, Geneviève ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Francois, Carole ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Jasik, Agnieszka
Burny, Arsène ;  Université de Liège - ULiège > Agro Biotech Gembloux
Kettmann, Richard ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research - Gembloux Agro-Bio Tech
Language :
English
Title :
Earlier onset of delta-retrovirus-induced leukemia after splenectomy.
Publication date :
2009
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, San Franscisco, United States - California
Volume :
4
Issue :
9
Pages :
e6943
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 December 2009

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