[en] The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of different parameters on migration times, peak symmetry, efficiency and resolution was studied; these parameters included the nature and concentration of the anionic and cationic components of the separation buffer. A buffer consisting of 75 mM glycine adjusted to pH 9.1 with triethanolamine was found to provide a very efficient and stable electrophoretic system for the CZE analysis of NSAIDs, giving RSD values of about 0.1 and 0.5% for the within-day reproducibility of migration times and peak areas, respectively at a concentration of 25 micrograms ml-1 (n = 5). Response was linear from 2-100 micrograms ml-1 for both sulindac and tiaprofenic acid, for which the LOQ values were 2.8 and 1.9 micrograms ml-1, respectively, using UV detection at 280 nm. Accuracy for each drug was 102-103%.
Disciplines :
Chemistry
Author, co-author :
Bechet, Isabelle; Université de Liège - ULiège > Pharmacie > Analyse des Médicaments
Hubert, Philippe ; Université de Liège - ULiège > Département de Pharmacie > Chimie analytique
Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Quantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis
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Bibliography
Jorgenson, Lukacs Anal. Chem. 1981, 53:1298-1302.
Jorgenson, Lukacs J. Chromatogr. 1981, 218:209-216.
Weinberger, Albin J. Liquid Chromatogr. 1991, 14:953-972.
Donato, Van Den Eeckhout, Van Den Bossche, Sandra J. Pharm. Biomed. Anal. 1993, 11:197-201.
Donato, Baeyens, Van Den Bossche, Sandra J. Pharm. Biomed. Anal. 1994, 12:21-26.
Maboundou, Paintaud, Bérard, Bechtel J. Chromatogr. B. 1994, 657:173-183.
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