M.L. Gillison, L. Alemany, P.J. Snijders, A. Chaturvedi, B.M. Steinberg, S. Schwartz, and et al. Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis Vaccine 30 Suppl 5 2012 F34 F54
E. Kostareli, D. Holzinger, and J. Hess New concepts for translational head and neck oncology: lessons from HPV-related oropharyngeal squamous cell carcinomas Front Oncol 2 2012 36
C.R. Leemans, B.J. Braakhuis, and R.H. Brakenhoff The molecular biology of head and neck cancer Nat Rev Cancer 11 1 2011 9 22
K.K. Ang, J. Harris, R. Wheeler, R. Weber, D.I. Rosenthal, P.F. Nguyen-Tan, and et al. Human papillomavirus and survival of patients with oropharyngeal cancer N Engl J Med 363 1 2010 24 35
A.M. Chen, J. Li, L.A. Beckett, T. Zhara, G. Farwell, D.H. Lau, and et al. Differential response rates to irradiation among patients with human papillomavirus positive and negative oropharyngeal cancer Laryngoscope 123 1 2012 152 157
C. Fakhry, W.H. Westra, S. Li, A. Cmelak, J.A. Ridge, H. Pinto, and et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial J Natl Cancer Inst 100 4 2008 261 269
F.P. Worden, B. Kumar, J.S. Lee, G.T. Wolf, K.G. Cordell, J.M. Taylor, and et al. Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number J Clin Oncol 26 19 2008 3138 3146
P. Lassen, J.G. Eriksen, S. Hamilton-Dutoit, T. Tramm, J. Alsner, and J. Overgaard HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer Radiother Oncol 94 1 2010 30 35
P. Vaupel, D.K. Kelleher, and M. Hockel Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy Semin Oncol 28 2 Suppl 8 2001 29 35
M. Nordsmark, S.M. Bentzen, V. Rudat, D. Brizel, E. Lartigau, P. Stadler, and et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study Radiother Oncol 77 1 2005 18 24
N. Brockton, J. Dort, H. Lau, D. Hao, S. Brar, A. Klimowicz, and et al. High stromal carbonic anhydrase IX expression is associated with decreased survival in P16-negative head-and-neck tumors Int J Radiat Oncol Biol Phys 80 1 2011 249 257
Choi, H.G., J.S. Kim, K.H. Kim, K.H. Kim, M.W. Sung, J.Y. Choe, et al., Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance. Eur Arch Otorhinolaryngol, 2014.
S. Jo, A. Juhasz, K. Zhang, C. Ruel, S. Loera, S.P. Wilczynski, and et al. Human papillomavirus infection as a prognostic factor in oropharyngeal squamous cell carcinomas treated in a prospective phase II clinical trial Anticancer Res 29 5 2009 1467 1474
L.S. Mortensen, J. Johansen, J. Kallehauge, H. Primdahl, M. Busk, P. Lassen, and et al. FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial Radiother Oncol 105 1 2012 14 20
J.D. Troy, J.L. Weissfeld, A.O. Youk, S. Thomas, L. Wang, and J.R. Grandis Expression of EGFR, VEGF, and NOTCH1 suggest differences in tumor angiogenesis in HPV-positive and HPV-negative head and neck squamous cell carcinoma Head Neck Pathol 7 4 2013 344 355
M. Maalouf, G. Alphonse, A. Colliaux, M. Beuve, S. Trajkovic-Bodennec, P. Battiston-Montagne, and et al. Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinoma cell lines exposed to carbon ions and X-rays Int J Radiat Oncol Biol Phys 74 1 2009 200 209
C.C. Ragin, S.C. Reshmi, and S.M. Gollin Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line Int J Cancer 110 5 2004 701 709
R.D. Steenbergen, M.A. Hermsen, J.M. Walboomers, H. Joenje, F. Arwert, C.J. Meijer, and et al. Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line Cancer Res 55 22 1995 5465 5471
Guihard S, Ramolu L, Macabre C, Wasylyk B, Noel G, Abecassis J, et al. The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation. Int J Oncol, 2012.
A.C. Jung, J. Briolat, R. Millon, A. de Reynies, D. Rickman, E. Thomas, and et al. Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma Int J Cancer 126 8 2010 1882 1894
A.C. Jung, S. Guihard, S. Krugell, S. Ledrappier, A. Brochot, V. Dalstein, and et al. CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis Int J Cancer 132 2 2013 E26 E36
D.S. Rickman, R. Millon, A. De Reynies, E. Thomas, C. Wasylyk, D. Muller, and et al. Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays Oncogene 27 51 2008 6607 6622
M. Nakamura, J.M. Bodily, M. Beglin, S. Kyo, M. Inoue, and L.A. Laimins Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses Virology 387 2 2009 442 448
R. Alarcon, C. Koumenis, R.K. Geyer, C.G. Maki, and A.J. Giaccia Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation Cancer Res 59 24 1999 6046 6051
C. Koumenis, R. Alarcon, E. Hammond, P. Sutphin, W. Hoffman, M. Murphy, and et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation Mol Cell Biol 21 4 2001 1297 1310
B. Wasylyk, J. Abecassis, and A.C. Jung Identification of clinically relevant HPV-related HNSCC: in p16 should we trust? Oral Oncol 49 10 2013 e33 e37
J.M. Bodily, K.P. Mehta, and L.A. Laimins Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases Cancer Res 71 3 2011 1187 1195
X. Tang, Q. Zhang, J. Nishitani, J. Brown, S. Shi, and A.D. Le Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells Clin Cancer Res 13 9 2007 2568 2576
P. Lassen, J.G. Eriksen, A. Krogdahl, M.H. Therkildsen, B.P. Ulhoi, M. Overgaard, and et al. The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: evaluation of the randomised DAHANCA 6&7 trial Radiother Oncol 100 1 2011 49 55