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Cell based advanced therapeutic medicinal products for bone repair: Keep it simple?

Leijten, J.; Chai, Y. C.; Papantoniou, I. et al.

2015 • In Advanced Drug Delivery Reviews, 84, p. 30-44

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https://hdl.handle.net/2268/183854

DOI
10.1016/j.addr.2014.10.025

PubMed
25451134

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Keywords :

Enabling technology; Musculoskeletal; Regenerative medicine; Stem cell; Therapy; Tissue engineering

Abstract :

[en] The development of cell based advanced therapeutic medicinal products (ATMPs) for bone repair has been expected to revolutionize the health care system for the clinical treatment of bone defects. Despite this great promise, the clinical outcomes of the few cell based ATMPs that have been translated into clinical treatments have been far from impressive. In part, the clinical outcomes have been hampered because of the simplicity of the first wave of products. In response the field has set-out and amassed a plethora of complexities to alleviate the simplicity induced limitations. Many of these potential second wave products have remained "stuck" in the development pipeline. This is due to a number of reasons including the lack of a regulatory framework that has been evolving in the last years and the shortage of enabling technologies for industrial manufacturing to deal with these novel complexities. In this review, we reflect on the current ATMPs and give special attention to novel approaches that are able to provide complexity to ATMPs in a straightforward manner. Moreover, we discuss the potential tools able to produce or predict 'goldilocks' ATMPs, which are neither too simple nor too complex.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Leijten, J.

Chai, Y. C.

Papantoniou, I.

Geris, Liesbet ; Université de Liège > Département d'aérospatiale et mécanique > Génie biomécanique

Schrooten, J.

Luyten, F. P.

Language :

English

Title :

Cell based advanced therapeutic medicinal products for bone repair: Keep it simple?

Publication date :

2015

Journal title :

Advanced Drug Delivery Reviews

ISSN :

0169-409X

eISSN :

1872-8294

Publisher :

Elsevier, Netherlands

Volume :

84

Pages :

30-44

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Copyright (c) 2014 Elsevier B.V. All rights reserved.

Available on ORBi :

since 08 July 2015

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39

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28

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34

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