Reference : Method for the preparation of reactive [18F]fluoride
Patent : Patent
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/183557
Method for the preparation of reactive [18F]fluoride
English
Voccia, Samuel [Trasis > > > >]
Aerts, Joël mailto [Université de Liège > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
Morelle, Jean-Luc mailto [Trasis > > > >]
Philippart, Gauthier mailto [Trasis SA > > > >]
30-Oct-2008
2007-04-23
World Intellectual property Organization
WO 2008/128306 A1
07008220.1
B
international Bureau
Université de Liège
COIB 9108 BOJD 15136 C07B 59100
?
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM,ZW.
ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
[en] The invention is related to a method to obtain reactive [18F] fluorides in an org. medium suitable for radiolabeling without any azeotropic evapn. step, using a solid phase extn. column contg. a modified non- ionic solid support. The SS is selected from extn. resins and liq. chromatog. resins comprising polar and nonpolar phases functionalized with or made of alkyl chains comprising 1 to 30 carbon atoms, polystyrene, cyclohexyl, poly(divinylbenzene)​, poly(styrene-​5-​divinylbenzene)​, Ph, polyamide, aminopropyl (NH2)​, cyanopropyl (CN)​, alcs. or diols, carboxymethyl, hydroxylated poly(styrene-​divinylbenzene)​, diethylaminoethyl, quaternary aminoethyl or sulfopropyl. Said vinyl comonomer is selected from the group consisting of vinylpyrrolidone, vinyl acetate, (methacryloyloxymethyl)​naphthalene, 4,​4'-​bis(maleimido)​diphenylmethane, p,​p'-​dihydroxydiphenylmethane diglycidylmethacrylic ester, p,​p'-​dihydroxydiphenylpropane diglycidylmethacrylic ester, 2-​hydroxyethyl methacrylate (HEMA)​, 2,​2-​dimethylaminoethyl methacrylate (DMAEMA)​, ethylenedimethacrylate glycidyl methacrylate, N-​vinylcarbazole, acrylonitrile, vinylpyridine, N-​methyl-​N-​vinylacetamide, aminostyrene, -​30-​Me acrylate, Et acrylate, Me methacrylate, N-​vinylcaprolactam, N-​methyl-​N-​vinylacetamide. Said metal salt cation is selected from the alkali group, preferably lithium, sodium, potassium, rubidium and cesium, the alk. earth metal group, preferably magnesium, calcium, strontium and barium, and the ammonium cation (NH4+)​; - said salt is selected from the group of halogenides, preferably fluor, chlor, brome, and iode, hydroxide, carbonates, phosphates, sulfates, carboxylates, acetate, alcoholates and perchlorate; - a complexing agent is selected from the group consisting of cryptands, including kryptofixs, such as 1,​4,​10-​Trioxa-​7,​13-​diazacyclopentadecane, 4,​7,​13,​16,​21,​24-​Hexaoxa-​1,​10-​diazabicyclo[8.8.8]​hexacosane, 4,​7,​13,​16,​21-​Pentaoxa-​1,​10-​diazabicyclo[8.8.5]​tricosane, 4,​7,​13,​18-​Tetraoxa-​1,​10-​diazabicyclo[8.5.5]​eicosane, 5,​6-​Benzo-​4,​7,​13,​16,​21,​24-​hexaoxa-​1,​10-​diazabicyclo[8.8.8]​hexacos-​5-​ene.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/183557

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