[en] Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and Near Infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50-150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Mbinze Kidenge, Jérémie ✱
Sacre, Pierre-Yves ✱; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Yemoa, Achille
Mavar Tayey Mbay, Jean
Habyalimana, Védaste
Kalenda, Nick
Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Debrus, B., Lebrun, P., Mbinze Kindenge, J., Lecomte, F., Ceccato, A., Caliaro, G., Mavar Tayey Mbay, J., Hubert, P., Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space (2011) J. Chromatogr. A, 1218, pp. 5205-5215
Mariama, K.C., Guillaume, S.S., Bougouma, E.C., Diarra, A., Ouédraogo, A., Dolo, A., Troye-Blomberg, M., Nebié, I., Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso (2015) Acta Trop., 142, pp. 41-46
Ambroise, T., Traitement du paludisme: prévenir les résistances par les associations d'antipaludiques (2000) Med. Trop., 60, pp. 219-222
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial (2005) Lancet, 366, pp. 717-725
Fenoff, R.S., Wilson, J.M., (2009) Africa's Counterfeit Pharmaceutical Epidemic: The Road Ahead, , A-CAPP Paper Series, Michigan State University
Nayyar, G.M.L., Breman, J.G., Newton, P.N., Herrington, J., Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa (2012) Lancet Infect. Dis., 12, pp. 488-496
Clift, C., (2010) Combating Counterfeit, Falsified and Substandard Medicines Defining the Way Forward, , Chatham House Briefing Papers
Marini, R.D., Mbinze, J.K., Aja montes, M.L., Bebrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Hubert, P., Analytical tools to fight against counterfeit medicines (2010) Chim. Oggi, 28, pp. 10-14
Ziemons, E., Mantanus, J., Lebrun, P., Rozet, E., Evrard, B., Hubert, P., Acetaminophen determination in low-dose pharmaceutical syrup by NIR spectroscopy (2010) J. Pharm. Biomed. Anal., 53, pp. 510-516
Mantanus, J., Rozet, E., Van Butsele, K., De Bleye, C., Ceccato, A., Evrard, B., Hubert, P., Ziemons, E., Near infrared and Raman spectroscopy as process analytical technology tools for the manufacturing of silicone-based drug reservoirs (2011) Anal. Chim. Acta, 699, pp. 96-106
Lyndgaard, L.B., Van den Berg, F., De Juan, A., Quantification of paracetamol through tablet blister packages by Raman spectroscopy and multivariate curve resolution-alternating least squares (2013) Chemom. Intell. Lab. Syst., 125, pp. 58-66
Rodionova, O.Y., Pomerantsev, A.L., NIR-based approach to counterfeit-drug detection (2010) TrAC Trends Anal. Chem., 29, pp. 795-803
Bate, R., Tren, R., Hess, K., Mooney, L., Porter, K., Pilot study comparing technologies to test for substandard drugs in field settings (2009) Afr. J. Pharm. Pharmacol., 3, pp. 165-170
Dowell, F.E., Maghirang, E.B., Fernandez, F.M., Newton, P.N., Green, M.D., Detecting counterfeit antimalarial tablets by near-infrared spectroscopy (2008) J. Pharm. Biomed. Anal., 48, pp. 1011-1014
Sacré, P.-Y., Deconinck, E., De Beer, T., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., De Beer, J., Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines (2010) J. Pharm. Biomed. Anal., 53, pp. 445-453
Burns, D.A., Ciurczak, E.W., (2008) Handbook of Near-Infrared Analysis, , CRC Press, New York
Hubert, P., Nguyen-Huu, J.J., Boulanger, B., Chapuzet, E., Chiap, P., Cohen, N., Compagnon, P.A., Valat, L., Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal. Part I (2004) J. Pharm. Biomed. Anal., 36, pp. 579-586
Bland, J.M., Altman, D.G., Statistical methods for assessing agreement between two methods of clinical measurement (1986) Lancet, pp. 307-310
Savitzky, A., Golay, M.J.E., Smoothing and differentiation of data by simplified least squares procedures (1964) Anal. Chem., 36, pp. 1627-1639
De Bleye, C., Chavez, P.-F., Mantanus, J., Marini, R., Hubert, P., Rozet, E., Ziemons, E., Critical review of near-infrared spectroscopic methods validations in pharmaceutical applications (2012) J. Pharm. Biomed. Anal., 69, pp. 125-132
(1995) United States Pharmacopoeia, 23, p. 1358
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