Reference : Biodistribution and radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H: Fi...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/176596
Biodistribution and radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H: First-in-human study.
English
Bretin, Florian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Bahri, Mohamed Ali mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
BERNARD, Claire mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco >]
Warnock, Geoffrey []
Aerts, Joël mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Mestdagh, Nathalie []
Buchanan, T []
Otoul, C []
Koestler, F []
Mievis, Frédéric mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Giacomelli, Fabrice mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Degueldre, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Hustinx, Roland mailto [Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire >]
Luxen, André mailto [Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
Seret, Alain mailto [Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale >]
Plenevaux, Alain mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Salmon, Eric mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
17-Jan-2015
Molecular Imaging and Biology
Springer
17
557-564
Yes (verified by ORBi)
International
1536-1632
New York
NY
[en] Radiotracer ; Human dosimetry ; Brain ; PET ; SV2A ; Translational
[en] Abstract- [18F]UCB-H is a novel radiotracer with a high affinity for SV2A, a protein expressed in synaptic vesicles. SV2A is the binding site of levetiracetam, a “first in class” antiepileptic drug with a distinct but still poorly understood mechanism of action. The objective of this study was to determine the biodistribution and radiation dosimetry of [18F]UCB-H in a human clinical trial and to establish injection limits according to biomedical research guidelines. Additionally, the clinical radiation dosimetry results were compared to estimations in previously published preclinical data. Dynamic whole body PET/CT imaging was performed over approximately 110 minutes on five healthy male volunteers after injection of 144.5 ± 7.1 MBq (range, 139.1 – 156.5 MBq) of [18F]UCB-H. Major organs were delineated on CT images and time-activity curves were obtained from co-registered dynamic PET emission scans. Time-integrated activity coefficients were calculated as area under the curve using trapezoidal numerical integration. Urinary excretion data based on PET-activities including voiding was simulated using the dynamic bladder module of OLINDA/EXM. The radiation dosimetry was calculated using OLINDA/EXM. The effective dose to the OLINDA/EXM 70 kg standard male was 1.54E-02 ± 6.84E-04 mSv/MBq, with urinary bladder wall, gallbladder wall and the liver receiving the highest absorbed dose. The brain, the tracer’s main organ of interest, received an absorbed dose of 1.89E-02 ± 2.32E-03 mGy/MBq. This first human dosimetry study of [18F]UCB-H indicated that the tracer shows similar radiation burdens to widely used common clinical tracers. Single injections of at maximum 672 MBq for USA practice and 649 MBq for European practice keep radiation exposure below recommended limits. Recently published preclinical dosimetry data extrapolated from mice provided satisfactory prediction of total body and effective dose, but showed significant differences in organ absorbed doses compared to human data.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/176596
10.1007/s11307-014-0820-6
http://link.springer.com/article/10.1007/s11307-014-0820-6

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