Reference : Natural killer and dendritic cells collaborate in the immune response induced by the ...
Scientific journals : Article
Life sciences : Microbiology
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/172893
Natural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.
English
Langers, Inge [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Virologie >]
Renoux, Virginie [> >]
Reschner, Anca [> >]
Touze, Antoine [> >]
Coursaget, Pierre [> >]
Boniver, Jacques mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Koch, Joachim [> >]
Delvenne, Philippe mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Jacobs, Nathalie mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Virologie >]
Dec-2014
European Journal of Immunology
44
3585-3595
Yes (verified by ORBi)
International
0014-2980
1521-4141
[en] Cell crosstalk ; DC ; HPV Vaccines ; NK cells ; Vaccination ; Viral infection
[en] Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since NK cells collaborate with dendritic cells (DCs) to induce an immune response against viral infections and tumors, we studied the impact of this crosstalk in the context of HPV vaccination. NK cells in the presence of HPV-VLPs enhanced DC maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10. This activation was bi-directional. Indeed, in the presence of HPV-VLPs, DCs further activated NK cells by inducing the upregulation of cell surface activation markers (CD69 and HLA-DR). The function of NK cells was also improved as shown by an increase in IFN-gamma secretion and cytotoxic activity against an HPV+ cell line. This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated. Our results provide insight into how VLPs interact with innate immune cells and how NK cells and DCs play a role in the immune response induced by this vaccine agent. This article is protected by copyright. All rights reserved.
Giga-Infection, Immunity and Inflammation
Fonds Léon Fredericq ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Students
http://hdl.handle.net/2268/172893
10.1002/eji.201444594
http://onlinelibrary.wiley.com/doi/10.1002/eji.201444594/abstract
This article is protected by copyright. All rights reserved.

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