Natural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.

Langers, Inge; Renoux, Virginie; Reschner, Anca; Touze, Antoine; Coursaget, Pierre; Boniver, Jacques; Koch, Joachim; Delvenne, Philippe; Jacobs, Nathalie

doi:10.1002/eji.201444594

Article (Scientific journals)

Natural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.

Langers, Inge; Renoux, Virginie; Reschner, Anca et al.

2014 • In European Journal of Immunology, 44, p. 3585-3595

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/172893

DOI
10.1002/eji.201444594

PubMed
25229656

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Keywords :

Cell crosstalk; DC; HPV Vaccines; NK cells; Vaccination; Viral infection

Abstract :

[en] Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since NK cells collaborate with dendritic cells (DCs) to induce an immune response against viral infections and tumors, we studied the impact of this crosstalk in the context of HPV vaccination. NK cells in the presence of HPV-VLPs enhanced DC maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10. This activation was bi-directional. Indeed, in the presence of HPV-VLPs, DCs further activated NK cells by inducing the upregulation of cell surface activation markers (CD69 and HLA-DR). The function of NK cells was also improved as shown by an increase in IFN-gamma secretion and cytotoxic activity against an HPV+ cell line. This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated. Our results provide insight into how VLPs interact with innate immune cells and how NK cells and DCs play a role in the immune response induced by this vaccine agent. This article is protected by copyright. All rights reserved.

Research Center/Unit :

GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège

Disciplines :

Immunology & infectious disease
Microbiology

Author, co-author :

Langers, Inge ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Virologie

Renoux, Virginie

Reschner, Anca

Touze, Antoine

Coursaget, Pierre

Boniver, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Koch, Joachim

Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Jacobs, Nathalie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Virologie

Language :

English

Title :

Natural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.

Publication date :

December 2014

Journal title :

European Journal of Immunology

ISSN :

0014-2980

eISSN :

1521-4141

Publisher :

John Wiley & Sons, United Kingdom

Volume :

Pages :

3585-3595

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://onlinelibrary.wiley.com/doi/10.1002/eji.201444594/abstract

Funders :

Fonds Léon Fredericq
F.R.S.-FNRS - Fonds de la Recherche Scientifique

Commentary :

Available on ORBi :

since 11 October 2014

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