Sensitivity analysis of circadian entrainment in the space of phase response curves
Sacré, Pierre; Sepulchre, Rodolphe
2014 • In Kulkarni, Vishwesh V.; Stan, Guy-Bart; Raman, Karthik (Eds.) A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems
[en] Sensitivity analysis is a classical and fundamental tool to evaluate the role of a given parameter in a given system characteristic. Because the phase response curve is a fundamental input–output characteristic of oscillators, we developed a sensitivity analysis for oscillator models in the space of phase response curves. The proposed tool can be applied to high-dimensional oscillator models without facing the curse of dimensionality obstacle associated with numerical exploration of the parameter space. Application of this tool to a state-of-the-art model of circadian rhythms suggests that it can be useful and instrumental to biological investigations.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Sacré, Pierre ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Sepulchre, Rodolphe ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Language :
English
Title :
Sensitivity analysis of circadian entrainment in the space of phase response curves
Publication date :
2014
Main work title :
A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems
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