Reference : PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/170017
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
English
Bajou, Khalid mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Herkenne, Stéphanie mailto [Université de Liège - ULiège > > R&D Direction : Chercheurs ULiège en mobilité >]
Thijssen, Victor L. [> >]
D'Amico, Salvino [> >]
Nguyen, Ngoc-Quynh-Nhu [> >]
Bouche, Ann [> >]
Tabruyn, Sébastien [> >]
Srahna, Mohammed [> >]
Carabin, Jean-Yves [> >]
Nivelles, Olivier mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Paques, Cécile mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Cornelissen, Yvo [> >]
Lion, Michelle mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Noël, Agnès mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Gils, Ann [> >]
Vinckier, Stefan [> >]
Declerck, Paul J. [> >]
Griffioen, Arjan W. [> >]
Dewerchin, Mieke [> >]
Martial, Joseph mailto [Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie >]
Carmeliet, Peter [> >]
Struman, Ingrid mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
2014
Nature Medicine
Nature Publishing Group
sous presse
Yes (verified by ORBi)
International
1078-8956
1546-170X
New York
NY
[en] The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor angiogenesis and growth. Loss of PAI-1 abrogated the antitumoral and antiangiogenic effects of 16K PRL. PAI-1 bound the ternary complex PAI-1-urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR), thereby exerting antiangiogenic effects. By inhibiting the antifibrinolytic activity of PAI-1, 16K PRL also protected mice against thromboembolism and promoted arterial clot lysis. Thus, by signaling through the PAI-1-uPA-uPAR complex, 16K PRL impairs tumor vascularization and growth and, by inhibiting the antifibrinolytic activity of PAI-1, promotes thrombolysis.
http://hdl.handle.net/2268/170017
10.1038/nm.3552
http://reflexions.ulg.ac.be/en/16KPRLthrombosis

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Bajou K Nat Med 2014.pdfPublisher postprint1.51 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.