Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation

[en] Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Navet, Rachel ; Université de Liège - ULiège > GIGA - Formation

Mathy, Grégory ; Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire

Douette, Pierre ; Université de Liège - ULiège > Bioénergétique et physiologie cellulaire

Dobson, Rowan ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse

Leprince, Pierre ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

De Pauw, Edwin ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse

Sluse-Goffart, Claudine; Université de Liège - ULiège

Sluse, Francis ; Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire

Language :

English

Title :

Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation

Publication date :

05 January 2007

Journal title :

Journal of Proteome Research

ISSN :

1535-3893

eISSN :

1535-3907

Publisher :

Amer Chemical Soc, Washington, United States - Washington

Volume :

Issue :

Pages :

25-33

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 December 2008

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