Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation

Navet, Rachel; Mathy, Grégory; Douette, Pierre; Dobson, Rowan; Leprince, Pierre; De Pauw, Edwin; Sluse-Goffart, C.; Sluse, Francis

doi:10.1021/pr060064u

Reference : Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/1690

Title :	Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation
Language :	English
Author, co-author :	Navet, Rachel [Université de Liège - ULiège > > GIGA - Formation >]
	Mathy, Grégory [Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
	Douette, Pierre [Université de Liège - ULiège > > Bioénergétique et physiologie cellulaire >]
	Dobson, Rowan [Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse >]
	Leprince, Pierre [Université de Liège - ULiège > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
	De Pauw, Edwin [Université de Liège - ULiège > > Chimie physique, spectrométrie de masse >]
	Sluse-Goffart, C. [> > > >]
	Sluse, Francis [Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
Publication date :	5-Jan-2007
Journal title :	Journal of Proteome Research
Publisher :	Amer Chemical Soc
Volume :	6
Issue/season :	1
Pages :	25-33
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1535-3893
City :	Washington
Keywords :	[en] proteomics ; 2 D-DIGE ; brown adipose tissue ; uncoupling protein 1 ; cold acclimation ; thermogenesis
Abstract :	[en] Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling.
Target :	Researchers ; Students
Permalink :	http://hdl.handle.net/2268/1690
DOI :	10.1021/pr060064u

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