Les proteines SIBLING - Outils moleculaires de la progression tumorale et de l'angiogenese.

Animals; Carcinogenesis; Cell Adhesion; Cell Movement; Cell Proliferation; Extracellular Matrix Proteins/physiology; Glycoproteins/physiology; Humans; Integrin-Binding Sialoprotein/blood/physiology; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms/pathology; Neovascularization, Pathologic; Osteopontin/physiology; Phosphoproteins/physiology; Sialoglycoproteins/physiology

Abstract :

[en] The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). These proteins, initially identified in bone and teeth, share many structural characteristics. It is now well established that they are over expressed in many tumors and play a critical role at different steps of cancer development. In this review, we describe the roles of SIBLING proteins at different stages of cancer progression including cancer cell adhesion, proliferation, migration, invasion, metastasis and angiogenesis.

Research center :

Giga-Cancer - ULiège

Disciplines :

Oncology
Biochemistry, biophysics & molecular biology

Author, co-author :

Lamour, Virginie

Nokin, Marie-Julie ; Université de Liège - ULiège > GIGA - Membres

Henry, Aurélie ; Université de Liège - ULiège > GIGA - Membres

Castronovo, Vincenzo ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire

Bellahcene, Akeila ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases

Language :

French

Title :

Les proteines SIBLING - Outils moleculaires de la progression tumorale et de l'angiogenese.

Alternative titles :

[en] SIBLING proteins: molecular tools for tumor progression and angiogenesis

Publication date :

2013

Journal title :

MS. Medecine Sciences

ISSN :

0767-0974

eISSN :

1958-5381

Publisher :

Editions EDK, France

Volume :

Issue :

Pages :

1018-25

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 11 April 2014

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Bibliography

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