Les proteines SIBLING - Outils moleculaires de la progression tumorale et de l'angiogenese.

Animals; Carcinogenesis; Cell Adhesion; Cell Movement; Cell Proliferation; Extracellular Matrix Proteins/physiology; Glycoproteins/physiology; Humans; Integrin-Binding Sialoprotein/blood/physiology; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms/pathology; Neovascularization, Pathologic; Osteopontin/physiology; Phosphoproteins/physiology; Sialoglycoproteins/physiology

Abstract :

[en] The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). These proteins, initially identified in bone and teeth, share many structural characteristics. It is now well established that they are over expressed in many tumors and play a critical role at different steps of cancer development. In this review, we describe the roles of SIBLING proteins at different stages of cancer progression including cancer cell adhesion, proliferation, migration, invasion, metastasis and angiogenesis.

Research Center/Unit :

Giga-Cancer - ULiège

Disciplines :

Oncology
Biochemistry, biophysics & molecular biology

Author, co-author :

Lamour, Virginie

Nokin, Marie-Julie ; Université de Liège - ULiège > GIGA - Membres

Henry, Aurélie ; Université de Liège - ULiège > GIGA - Membres

Castronovo, Vincenzo ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire

Bellahcene, Akeila ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases

Language :

French

Title :

Les proteines SIBLING - Outils moleculaires de la progression tumorale et de l'angiogenese.

Alternative titles :

[en] SIBLING proteins: molecular tools for tumor progression and angiogenesis

Publication date :

2013

Journal title :

MS. Medecine Sciences

ISSN :

0767-0974

eISSN :

1958-5381

Publisher :

Editions EDK, France

Volume :

Issue :

Pages :

1018-25

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 11 April 2014

Statistics

Number of views

156 (22 by ULiège)

Number of downloads

294 (4 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Fisher, LW; Fedarko, NS. Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res 2003; 44: 33-40. (Pubitemid 36395419)
Bellahcene, A; Castronovo, V; Ogbureke, KU; et al. Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat Rev Cancer 2008; 8: 212-226. (Pubitemid 351301854)
Staines, KA; MacRae, VE; Farquharson, C. The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. J Endocrinol 2012; 214: 241-255.
El-Tanani, MK; Campbell, FC; Kurisetty, V; et al. The regulation and role of osteopontin in malignant transformation and cancer. Cytokine Growth Factor Rev 2006; 17: 463-474. (Pubitemid 44793123)
Hanahan, D; Weinberg, RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
Sung, V; Stubbs, JT, III, Fisher, L; et al. Bone sialoprotein supports breast cancer cell adhesion proliferation and migration through differential usage of the alpha(v)beta3 and alpha(v)beta5 integrins. J Cell Physiol 1998; 176: 482-494. (Pubitemid 28383909)
Lee, JL; Wang, MJ; Sudhir, PR; et al. Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells. Cancer Res 2007; 67: 2089-2097.
Pecheur, I; Peyruchaud, O; Serre, CM; et al. Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone. Faseb J 2002; 16: 1266-1268.
von Marschall, Z; Fisher, LW. Dentin matrix protein-1 isoforms promote differential cell attachment and migration. J Biol Chem 2008; 283: 32730-32740.
Khodavirdi, AC; Song, Z; Yang, S; et al. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res 2006; 66: 883-888. (Pubitemid 43165954)
Courter, D; Cao, H; Kwok, S; et al. The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. PLoS One 2010; 5: e9633.
Ahmed, M; Behera, R; Chakraborty, G; et al. Osteopontin: a potentially important therapeutic target in cancer. Expert Opin Ther Targets 2011; 15: 1113-1126.
Kayed, H; Kleeff, J; Keleg, S; et al. Effects of bone sialoprotein on pancreatic cancer cell growth, invasion and metastasis. Cancer Lett 2007; 245: 171-183. (Pubitemid 44959351)
Joshi, R; Tawfik, A; Edeh, N; et al. Dentin sialophosphoprotein (DSPP) gene-silencing inhibits key tumorigenic activities in human oral cancer cell line, OSC2. PLoS One 2010; 5: e13974.
Rangaswami, H; Kundu, GC. Osteopontin stimulates melanoma growth and lung metastasis through NIK/MEKK1-dependent MMP-9 activation pathways. Oncol Rep 2007; 18: 909-915.
Khan, SA; Cook, AC; Kappil, M; et al. Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation. Clin Exp Metastasis 2005; 22: 663-673. (Pubitemid 44259527)
Irby, RB; McCarthy, SM; Yeatman, TJ. Osteopontin regulates multiple functions contributing to human colon cancer development and progression. Clin Exp Metastasis 2004; 21: 515-523.
Yan, W; Qian, C; Zhao, P; et al. Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. Neuro Oncol 2010; 12: 765-775.
Sharp, JA; Waltham, M; Williams, ED; et al. Transfection of MDA-MB-231 human breast carcinoma cells with bone sialoprotein (BSP) stimulates migration and invasion in vitro and growth of primary and secondary tumors in nude mice. Clin Exp Metastasis 2004; 21: 19-29. (Pubitemid 38365654)
Takafuji, V; Forgues, M; Unsworth, E; et al. An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma. Oncogene 2007; 26: 6361-6371. (Pubitemid 47494216)
Mangala, LS; Arun, B; Sahin, AA; Mehta, K.; Tissue transglutaminase- induced alterations in extracellular matrix inhibit tumor invasion. Mol Cancer 2005; 4: 33.
Fedarko, NS; Jain, A; Karadag, A; Fisher, LW. Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases. Faseb J 2004; 18: 734-736.
Fisher, LW; Jain, A; Atayback, M; Fedarko, NS. Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers. Clin Cancer Res 2004; 10: 8501-8511. (Pubitemid 40053416)
Ogbureke, KU; Nikitakis, NG; Warburton, G; et al. Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer. Oral Oncol 2007; 43: 920-932. (Pubitemid 47376828)
Karadag, A; Ogbureke, KU; Fedarko, NS; Fisher, LW. Bone sialoprotein, matrix metalloproteinase 2, and alpha(v)beta3 integrin in osteotropic cancer cell invasion. J Natl Cancer Inst 2004; 96: 956-965. (Pubitemid 38868142)
Karadag, A; Fedarko, NS; Fisher, LW. Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44. Cancer Res 2005; 65: 11545-11552. (Pubitemid 41821713)
Fedarko, NS; Fohr, B; Robey, PG; et al. Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack. J Biol Chem 2000; 275: 16666-16672. (Pubitemid 30398895)
Jain, A; Karadag, A; Fohr, B; et al. Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H-s cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. J Biol Chem 2002; 277: 13700-13708. (Pubitemid 34967971)
Fidler, IJ. The pathogenesis of cancer metastasis: the 'seed and soil-hypothesis revisited. Nat Rev Cancer 2003; 3: 453-458. (Pubitemid 37328849)
Wai, PY; Kuo, PC. Osteopontin: regulation in tumor metastasis. Cancer Metastasis Rev 2008; 27: 103-118.
Oates, AJ; Barraclough, R; Rudland, PS. The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model. Oncogene 1996; 13: 97-104. (Pubitemid 26248549)
Adwan, H; Bauerle, TJ; Berger, MR. Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells. Cancer Gene Ther 2004; 11: 109-120. (Pubitemid 38141773)
Mandelin, J; Lin, EC; Hu, DD; et al. Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin. Cancer 2009; 115: 1753-1764.
Bellahcene, A; Merville, MP; Castronovo, V. Expression of bone sialoprotein, a bone matrix protein, in human breast cancer. Cancer Res 1994; 54: 2823-2826. (Pubitemid 24187753)
Waltregny, D; Bellahcene, A; Van Riet, I; et al. Prognostic value of bone sialoprotein expression in clinically localized human prostate cancer. J Natl Cancer Inst 1998; 90: 1000-1008. (Pubitemid 28340442)
Kang, Y; Siegel, PM; Shu, W; et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003; 3: 537-549. (Pubitemid 36808649)
Zhang, JH; Tang, J; Wang, J; et al. Over-expression of bone sialoprotein enhances bone metastasis of human breast cancer cells in a mouse model. Int J Oncol 2003; 23: 1043-1048.
Zhang, JH; Wang, J; Tang, J; et al. Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells. Anticancer Res 2004; 24: 1361-1368. (Pubitemid 38954650)
Koeneman, KS; Yeung, F; Chung, LW. Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment. Prostate 1999; 39: 246-261. (Pubitemid 29244499)
Bellahcene, A; Bachelier, R; Detry, C; et al. Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells. Breast Cancer Res Treat 2007; 101: 135-148. (Pubitemid 46115420)
Barnes, GL; Javed, A; Waller, SM; et al. Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Res 2003; 63: 2631-2637. (Pubitemid 36605206)
Brooks, PC; Clark, RA; Cheresh, DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994; 264: 569-571.
Wang, Y; Yan, W; Lu, X; et al. Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avbeta3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells. Eur J Cell Biol 2011; 90: 642-648.
Cui, R; Takahashi, F; Ohashi, R; et al. Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice. Lung Cancer 2007; 57: 302-310. (Pubitemid 47285419)
Dai, J; Peng, L; Fan, K; et al. Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells. Oncogene 2009; 28: 3412-3422.
Blasberg, JD; Goparaju, CM; Pass, HI; Donington, JS. Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. J Thorac Cardiovasc Surg 2010; 139: 1587-1593.
Bellahcene, A; Bonjean, K; Fohr, B; et al. Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis. Circ Res 2000; 86: 885-891. (Pubitemid 30246986)
Pirotte, S; Lamour, V; Lambert, V; et al. Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood 2011; 117: 2515-2526.
Bucciarelli, E; Sidoni, A; Bellezza, G; et al. Low dentin matrix protein 1 expression correlates with skeletal metastases development in breast cancer patients and enhances cell migratory capacity in vitro. Breast Cancer Res Treat 2007; 105: 95-104. (Pubitemid 47282752)
Chabas, D. L-ostéopontine, une molécule aux multiples facettes. Med Sci (Paris) 2005; 21: 832-838. (Pubitemid 41494583)
Orian-Rousseau, V. CD44, un régulateur de la croissance et de l-invasion cellulaire. Med Sci (Paris) 2003; 19: 405-407.
Bidard, FC; Poupon, MF. Biologie du processus métastatique. Med Sci (Paris) 2012; 28: 89-95.