Article (Scientific journals)
Optimization of Yarrowia lipolytica's β-oxidation pathway for γ-decalactone production
Waché, Y.; Aguedo, Mario; LeDall, M.-T. et al.
2002In Journal of Molecular Catalysis B: Enzymatic, 19-20, p. 347-351
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Keywords :
Decenolide; Methyl ricinoleate; Yarrowia lipolytica; Bioconversion; Extraction; Oxidation; Yeast; Aroma compound; Genetic engineering
Abstract :
[en] The yeast Yarrowia lipolytica growing on methyl ricinoleate produces various lactones, γ-decalactone, the worthy aroma compound, 3-hydroxy-γ-decalactone without sensorial properties and two decenolides of various interest. Unfortunately, these three latter lactones are produced at high levels by this yeast, decreasing yields and complicating the extraction of γ-decalactone. In this study, the production of γ-decalactone was increased through a genetic engineering of the strain and the accumulation of the three other lactones was lowered. Theses results show that it is possible to improve the mastering of the complex β-oxidation pathway (the metabolic pathway involved in these bioconversions) by playing on genetic factors. © 2002 Elsevier Science B.V. All rights reserved.
Disciplines :
Biotechnology
Author, co-author :
Waché, Y.;  Laboratoire de Biotechnologie (IMSA) de l'Ensbana, Université de Bourgogne, 1 esplanade Erasme, 21000 Dijon, France
Aguedo, Mario ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
LeDall, M.-T.;  Laboratoire de Génétique des Microorganismes, INRA-CNRS, URA1925, 78850 Thiverval-Grignon, France
Nicaud, J.-M.;  Laboratoire de Génétique des Microorganismes, INRA-CNRS, URA1925, 78850 Thiverval-Grignon, France
Belin, J.-M.;  Laboratoire de Biotechnologie (IMSA) de l'Ensbana, Université de Bourgogne, 1 esplanade Erasme, 21000 Dijon, France
Language :
English
Title :
Optimization of Yarrowia lipolytica's β-oxidation pathway for γ-decalactone production
Publication date :
2002
Journal title :
Journal of Molecular Catalysis B: Enzymatic
ISSN :
1381-1177
eISSN :
1873-3158
Publisher :
Elsevier, Netherlands
Volume :
19-20
Pages :
347-351
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 February 2014

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