Pubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction.

Franssen, Delphine; Ioannou, Yiannis S.; Alvarez-Real, Alexandra; Gerard, Arlette; Mueller, Johanna K.; Heger, Sabine; Bourguignon, Jean-Pierre; Parent, Anne-Simone

doi:10.1016/j.reprotox.2013.10.006

Article (Scientific journals)

Pubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction.

Franssen, Delphine; Ioannou, Yiannis S.; Alvarez-Real, Alexandra et al.

2014 • In Reproductive Toxicology, (44), p. 63-72

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/161883

DOI
10.1016/j.reprotox.2013.10.006

PubMed
24316331

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Keywords :

Diethylstilbestrol; Hypothalamus; Kisspeptin; Leptin; Puberty

Abstract :

[en] We studied the effects of neonatal exposure to diethylstilbestrol (DES) on pubertal timing in female rats. We examined associated neuroendocrine changes and effects of prenatal food restriction. Age at vaginal opening was advanced after exposure to 10mug/kg/d of DES and delayed after 1mug/kg/d (subcutaneous injections). Using this lower dose, pulsatile GnRH secretion was slower at 25 days of age. Both doses reduced KiSS1 mRNA levels at 15 days of age. Using functional Kisspeptin promoter assay, 1 or 10muM DES reduced or increased KISS1 transcription, respectively. Leptin stimulatory effect on GnRH secretion in vitro (15 days of age) was reduced after prenatal food restriction and neonatal DES exposure (higher dose), both effects being cumulative. Thus, alterations in pubertal timing by DES neonatally are not unequivocally toward precocity, the level of exposure being critical. We provide evidence of neuroendocrine disruption and interaction with prenatal food availability.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology
Endocrinology, metabolism & nutrition
Pediatrics

Author, co-author :

Franssen, Delphine ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Ioannou, Yiannis S.

Alvarez-Real, Alexandra

Gerard, Arlette

Mueller, Johanna K.

Heger, Sabine

Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Parent, Anne-Simone ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Language :

English

Title :

Pubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction.

Publication date :

April 2014

Journal title :

Reproductive Toxicology

ISSN :

0890-6238

eISSN :

1873-1708

Publisher :

Elsevier, Netherlands

Issue :

Pages :

63-72

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 23 January 2014

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