[en] In this study we analyzed by ATR-IR and Raman spectroscopy the interaction between six major calixarene derivatives and two anticoagulants: warfarin and acenocoumarol. The six calixarene derivatives were: p-tert-butyl-calix[4]arene (C4), p-tert- butyl-calix[6]arene (C6) and p-tert-butyl-calix[8]arene (C8) and their ethyl-ester- derivatives: tetraester-p-tert-butyl-calix[4]arene (C4Es4), hexaester-p-tert-butyl- calix[6]arene (C6Es6), octaester-p-tert-butyl-calix[8]arene (C8Es8). The results showed the most intense interaction in terms of complex formation for the C6-acenocoumarol couple and for the C6-warfarin couple, respectively.
Research Center/Unit :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Tiuca, Ioana
Saponar, Alina
Bodoki, Andreea
Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Bodoki, Ede
Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Oprean, Radu
Language :
English
Title :
ATR-IR and Raman spectroscopic study of interaction between major calixarene derivatives and oral anticoagulants
Publication date :
2013
Journal title :
Farmacia
ISSN :
0014-8237
eISSN :
2065-0019
Publisher :
Centrul de Documentare Medicală, București, Romania
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