Towards Lipidomics of Low-Abundant Species for Exploring Tumor Heterogeneity Guided by High-Resolution Mass Spectrometry Imaging

Cimino, Jonathan; Calligaris, David; Far, Johann; Debois, Delphine; Blacher, Silvia; Sounni, Nor Eddine; Noël, Agnès; De Pauw, Edwin

doi:10.3390/ijms141224560

Article (Scientific journals)

Towards Lipidomics of Low-Abundant Species for Exploring Tumor Heterogeneity Guided by High-Resolution Mass Spectrometry Imaging

Cimino, Jonathan; Calligaris, David; Far, Johann et al.

2013 • In International Journal of Molecular Sciences, 14, p. 24560-24580

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/161494

DOI
10.3390/ijms141224560

PubMed
24351834

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Keywords :

MALDI mass spectrometry imaging;; FTICR mass spectrometry; lipidomics; hypoxia;; necrosis;; cancer

Abstract :

[en] Many studies have evidenced the main role of lipids in physiological and also pathological processes such as cancer, diabetes or neurodegenerative diseases. The identification and the in situ localization of specific low-abundant lipid species involved in cancer biology are still challenging for both fundamental studies and lipid marker discovery. In this paper, we report the identification and the localization of specific isobaric minor phospholipids in human breast cancer xenografts by FTICR MALDI imaging supported by histochemistry. These potential candidates can be further confirmed by liquid chromatography coupled with electrospray mass spectrometry (LC-ESI-MS) after extraction from the region of interest defined by MALDI imaging. Finally, this study highlights the importance of characterizing the heterogeneous distribution of low-abundant lipid species, relevant in complex histological samples for biological purposes.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Cimino, Jonathan ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)

Calligaris, David

Far, Johann ; Université de Liège - ULiège > Center for Analytical Research and Technology (CART)

Debois, Delphine ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)

Blacher, Silvia ; Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie

Sounni, Nor Eddine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

Noël, Agnès ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)

Language :

English

Title :

Towards Lipidomics of Low-Abundant Species for Exploring Tumor Heterogeneity Guided by High-Resolution Mass Spectrometry Imaging

Publication date :

2013

Journal title :

International Journal of Molecular Sciences

ISSN :

1661-6596

eISSN :

1422-0067

Publisher :

Molecular Diversity Preservation International (MDPI), Basel, Switzerland

Volume :

Pages :

24560-24580

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 January 2014

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