Reference : Development of a quantitative approach using surface-enhanced Raman chemical imaging:...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/158567
Development of a quantitative approach using surface-enhanced Raman chemical imaging: First step for the determination of an impurity in a pharmaceutical model
English
De Bleye, Charlotte* mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Sacre, Pierre-Yves* mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Dumont, Elodie mailto [Université de Liège - ULiège > > > 1re an. master sc. pharma., à finalité]
Netchacovitch, Lauranne mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Chavez, Pierre-François mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Piel, Géraldine mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Lebrun, Pierre mailto [Arlenda > > > >]
Hubert, Philippe mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Ziemons, Eric mailto [Université de Liège - ULiège > Département de pharmacie > Département de pharmacie >]
* These authors have contributed equally to this work.
5-Mar-2014
Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science
90
111-118
Yes (verified by ORBi)
International
0731-7085
1873-264X
Oxford
United Kingdom
[en] surface-enhanced Raman Scattering ; Chemical Imaging ; Pharmaceutical model ; Silver colloid covering ; Homogeneity study ; Quantitative approach
[en] This publication reports, for the first time, the development of a quantitative approach using surface-enhanced Raman chemical imaging (SER-CI). A pharmaceutical model presented as tablets based on paracetamol, which is the most sold drug around the world, was used to develop this approach. 4-Aminophenol is the main impurity of paracetamol and is actively researched in pharmaceutical formulations because of its toxicity. As its concentration is generally very low (<0.1%, w/w), conventional Raman chemical imaging cannot be used.
In this context, a SER-CI method was developed to quantify 4-aminophenol assessing a limit of quantification below its limit of specification of 1000 ppm. Citrate-reduced silver nanoparticles were used as SERS substrate and these nanoparticles were functionalized using 1-butanethiol. Different ways to cover the tablets surface by butanethiol-functionalized silver nanoparticles were tested and a homogeneity study of the silver nanoparticles covering was realized. This homogeneity study was performed in order to choose the best way to cover the surface of tablets by silver colloid. Afterwards, the optimization of the SER-CI approach was necessary and different spectral intensity normalizations were tested. Finally, a quantitative approach using SER-CI was developed enabling to quantify 4-aminophenol from 0.025% to 0.2% in paracetamol tablets. This quantitative approach was tested on two different series of tablets using different batches of silver nanoparticles.
Centre Interfacultaire de Recherche du Médicament - CIRM
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/158567

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