Reference : Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ d...
Scientific congresses and symposiums : Poster
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/155437
Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions.
English
[en] Inhibition de l'activité transformante de Tax avec une petite molecule ciblant les interactions Tax/PDZ.
Blibek, Karim mailto [Université de Liège - ULiège > > > GIGA - Membres]
Fujii, Naoaki []
Legros, Sebastien []
Boxus, Mathieu []
Dewulf, Jean-François []
Zimmermann, Pascale []
Kettmann, Richard mailto [Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc. >]
Dequiedt, Franck mailto [Université de Liège - ULiège > > GIGA-Research >]
Twizere, Jean-Claude mailto [Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc. >]
29-Jun-2013
A1
Yes
Yes
International
16th International Conference on Human Retrovirology: HTLV and Related Viruses HTLV
du 26 Juin au 30 Juin 2013.
Université de Montréal
Université du Québec à Montréal-UQAM
Montréal, Québec.
CANADA
[en] HTLV-1 ; Tax ; PDZ ; Transformation
[en] Primate T-lymphotropic virus species comprise four members (HTLV-1 to -4) that have been discovered in human. Only the HTLV-1 infection leads to adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis (TSP), an immune degenerative neurologic syndrome. All the four viruses share a similar genomic organization and encode transforming Tax oncoproteins. In contrast to HTLV-2 and 4, HTLV-1 and 3 Tax proteins contain a PSD-95/Drosophila Discs Large/Zona Occludens-I (PDZ) binding motif at their C-terminal that has been shown to play crucial roles in the distinct transforming properties of the Tax proteins. To systematically investigate PDZ-containing proteins roles in HTLV-1 biology, we initiated a global interactome network analysis of Tax and associated human PDZ-containing proteins. This was accomplished through the use of our framework of binary interactome mapping that includes stringent yeast two hybrid and pulldown screening, systematic retesting by protein complementation assay and evaluation of PDZ gene expression in T lymphocytes.
Giga-Signal Transduction
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Université de Liège ULg
Etude du rôle des protéines à domaines PDZ dans l'infection et la transformation des lymphocytes T par le virus de la leucémie humaine HTLV-1.
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/2268/155437

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