Reference : Dorsomedial prefrontal metabolism and unawareness of current characteristics of perso...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/154250
Dorsomedial prefrontal metabolism and unawareness of current characteristics of personality traits in Alzheimer’s disease
English
Jedidi, Haroun mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Feyers, Dorothée [Université de Liège - ULiège > Département Psychologies et cliniques des systèmes humains > Psychologie de la sénescence >]
Collette, Fabienne mailto [Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie >]
Bahri, Mohamed Ali mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Jaspar, Mathieu mailto [Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie >]
D'Argembeau, Arnaud mailto [Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Psychopathologie cognitive >]
Salmon, Eric mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Bastin, Christine mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
2014
Social Cognitive and Affective Neuroscience
Oxford University Press
9
10
1458-1463
Yes (verified by ORBi)
International
1749-5016
1749-5024
Oxford
United Kingdom
[en] DEMENTIA ; NEUROIMAGING ; SELF ; SOCIAL COGNITION ; UNAWARENESS
[en] Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while unawareness of current characteristics of personality traits has rarely been considered. We used a well-established questionnaire-based method in a group of 37 AD patients and in healthy controls to probe self- and hetero-evaluation of patients’ personality and we calculated differential scores between each participant’s and his/her relative’s judgments. A brain-behavior correlation was performed using FDG-PET images. The behavioral data showed that AD patients presented with anosognosia for current characteristics of their personality and their anosognosia was primarily explained by impaired third perspective taking. The brain-behavior correlation analysis revealed a negative relationship between anosognosia for current characteristics of personality and dorsomedial prefrontal cortex (dMPFC) activity. Behavioral and neuroimaging data are consistent with the view that impairment of different functions subserved by the dMPFC (self-evaluation, inferences regarding complex enduring dispositions of self and others, confrontation of perspectives in interpersonal scripts) plays a role in anosognosia for current characteristics of personality in AD patients.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Mécanismes de l'anosognosie, une étude sémiologique et par imagerie fonctionnelle.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/154250
10.1093/scan/nst132

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