Article (Scientific journals)
Brain metabolic dysfunction in Capgras delusion during Alzheimer’s disease: a positron emission tomography study
Jedidi, Haroun; Daury, Noémy; Rémi, Capa et al.
2015In American Journal of Alzheimer's Disease and Other Dementias, 30 (7), p. 699-706
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Keywords :
Capgras; Delusion of misidentification; Face recognition; Brain glucose metabolism; Neuroimaging
Abstract :
[en] Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer’s disease (AD) and Capgras syndrome was compared with those of 24 healthy elderly subjects and 26 AD patients without delusional syndrome. Compared to the healthy and AD groups, the patient had significant hypometabolism in frontal and posterior midline structures. In light of current neural models of face perception, our patient’s Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Jedidi, Haroun ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Daury, Noémy
Rémi, Capa
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Feyers, Dorothée ;  Université de Liège - ULiège > Département Psychologies et cliniques des systèmes humains > Psychologie de la sénescence
Bastin, Christine  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Brain metabolic dysfunction in Capgras delusion during Alzheimer’s disease: a positron emission tomography study
Publication date :
2015
Journal title :
American Journal of Alzheimer's Disease and Other Dementias
ISSN :
1533-3175
Publisher :
Sage
Volume :
30
Issue :
7
Pages :
699-706
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 28 May 2013

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