Capgras; Delusion of misidentification; Face recognition; Brain glucose metabolism; Neuroimaging
Abstract :
[en] Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer’s disease (AD) and Capgras syndrome was compared with those of 24 healthy elderly subjects and 26 AD patients without delusional syndrome. Compared to the healthy and AD groups, the patient had significant hypometabolism in frontal and posterior midline structures. In light of current neural models of face perception, our patient’s Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Jedidi, Haroun ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Daury, Noémy
Rémi, Capa
Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Feyers, Dorothée ; Université de Liège - ULiège > Département Psychologies et cliniques des systèmes humains > Psychologie de la sénescence
Bastin, Christine ; Université de Liège - ULiège > Centre de recherches du cyclotron
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Brain metabolic dysfunction in Capgras delusion during Alzheimer’s disease: a positron emission tomography study
Publication date :
2015
Journal title :
American Journal of Alzheimer's Disease and Other Dementias
ISSN :
1533-3175
Publisher :
Sage
Volume :
30
Issue :
7
Pages :
699-706
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Capgras J, Reboul-Lachaux J,. L'illusion des 'sosies' dans un délire systématisé chronique. Bull Soc Clin Med Mentale. 1923; 2: 6-16.
Josephs KA,. Capgras syndrome and its relationship to neurodegenerative disease. Arch Neurol. 2007; 64 (12): 1762-1766.
Edelstyn NM, Oyebode F,. A review of the phenomenology and cognitive neuropsychological origins of the Capgras syndrome. Int J Geriatr Psychiatry. 1999; 14 (1): 48-59.
Hirstein W, Ramachandran VS,. Capgras syndrome: a novel probe for understanding the neural representation of the identity and familiarity of persons. Proc Biol Sci. 1997; 264 (1380): 437-444.
Henriet K, Haouzir S, Petit M,. Capgras' syndrome: a delusional interpretation of a deficit of affective identification of face, Revue of literature and proposition of sequential model. Ann Med Psychol. 2008;(166): 147-156.
Frazer SJ, Roberts JM,. Three cases of Capgras' syndrome. Br J Psychiatry. 1994; 164 (4): 557-559.
Christodoulou GN., Treatment of the €syndrome of doubles€. Acta Psychiatr Belg. 1977; 77 (2): 254-259.
Todd J, Dewhurst K, Wallis G,. The syndrome of Capgras. Br J Psychiatry. 1981; 139: 319-327.
Young AW, Hellawell D, Wright S, and Ellis HD,. Reduplication of visual stimuli. Behav. Neurol. 1994;(7): 137-142.
Edelstyn NMJ, Oyebode F, Booker E., Humphreys GW, Facial processing and the delusional misidentification syndromes. Cog. Neuropsychiat. 1998; 3 (4): 299-314.
Paillere-Martinot ML, Dao-Castellana MH, Masure MC, Pillon B, Martinot JL., Delusional misidentification: a clinical, neuropsychological and brain imaging case study. Psychopathology. 1994; 27 (3-5): 200-210.
Cutting J,. Delusional misidentification and the role of the right hemisphere in the appreciation of identity. Br J Psychiatry Suppl. 1991;(14): 70-75.
Förstl H, Almeida OP, Owen AM, Burns A, Howard R,. Psychiatric, neurological and medical aspects of misidentification syndromes: a review of 260 cases. Psychol Med. 1991; 21 (4): 905-910.
Edelstyn NM, Oyebode F, Barrett K,. Delusional misidentification: a neuropsychological case study in dementia associated with Parkinson's disease. Neurocase. 1998;(4): 181-188.
Young AW, Reid I, Wright S, Hellawell DJ,. Face-processing impairments and the Capgras delusion. Br J Psychiatry. 1993; 162: 695-698.
Oyebode F, Sargeant R., Delusional misidentification syndromes: a descriptive study. Psychopathology. 1996; 29 (4): 209-214.
Cenac-Thaly H, Frelot C, Guinard M, Tricot JC, Lacour M., L'illusion des sosies[in French]. Ann Med Psychol. 1962; 120 (2): 481-494.
Damasio AR, Damasio H, Van Hoesen GW., Prosopagnosia: anatomic basis and behavioral mechanisms. Neurology. 1982; 32 (4): 331-341.
Walter-Ryan WG., Capgras' syndrome and misidentification. Am J Psychiatry. 1986; 143 (1): 126.
de Pauw KW., Psychodynamic approaches to the Capgras delusion: a critical historical review. Psychopathology. 1994; 27 (3-5): 154-160.
Ellis HD, Young AW, Quayle AH, De Pauw KW,. Reduced autonomic responses to faces in Capgras delusion. Proc Biol Sci. 1997; 264 (1384): 1085-1092.
Lewis SW,. Brain imaging in a case of Capgras' syndrome. Br J Psychiatry. 1987; 150: 117-121.
Bauer RM., Autonomic recognition of names and faces in prosopagnosia: a neuropsychological application of the Guilty Knowledge Test. Neuropsychologia. 1984; 22 (4): 457-469.
Tranel D, Damasio AR., Knowledge without awareness: an autonomic index of facial recognition by prosopagnosics. Science. 1985; 228 (4706): 1453-1454.
Ellis HD, Young AW., Accounting for delusional misidentifications. Br J Psychiatry. 1990; 157: 239-248.
Breen N, Caine D, Coltheart M., Models of face recognition and delusional misidentification: a critical review. Cogn Neuropsychol. 2000; 17 (1): 55-71.
Förstl H, Besthorn C, Burns A, Geiger-Kabisch C, Levy R, Sattel A., Delusional misidentification in Alzheimer's disease: a summary of clinical and biological aspects. Psychopathology. 1994; 27 (3-5): 194-199.
Silva JA, Leong GB, Wine DB., Misidentification delusions, facial misrecognition, and right brain injury. Can J Psychiatry. 1993; 38 (4): 239-241.
Joseph AB,. Focal central nervous system abnormalities in patients with misidentification syndromes. Bibl Psychiatr. 1986;(164): 68-79.
Silva JA, Leong GB, Lesser IM, Boone KB,. Bilateral cerebral pathology and the genesis of delusional misidentification. Can J Psychiatry. 1995; 40 (8): 498-499.
Signer SF., Localization and lateralization in the delusion of substitution. Capgras symptom and its variants. Psychopathology. 1994; 27 (3-5): 168-176.
Gallo DA, Chen JM, Wiseman AL, Schacter DL, Budson AE,. Retrieval monitoring and anosognosia in Alzheimer's disease. Neuropsychology. 2007; 21 (5): 559-568.
Baldwin RC, Snowden JS, Mann DM., Delusional misidentification in association with cortical Lewy body disease-a case report and overview of possible mechanisms. Int J Geriat Psychiat. 1995; 10 (10): 893-898.
Seltzer B, Sherwin I., A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two? Arch Neurol. 1983; 40 (3): 143-146.
Lebert F, Pasquier F, Steinling M, Cabaret M, Caparros-Lefebvre D, Petit H,. SPECT data in a case of secondary Capgras delusion. Psychopathology. 1994; 27 (3-5): 211-214.
Tueth MJ, Cheong JA., Successful treatment with pimozide of Capgras syndrome in an elderly male. J Geriatr Psychiatry Neurol. 1992; 5 (4): 217-219.
Todorov A, Gobbini MI, Evans KK, Haxby JV,. Spontaneous retrieval of affective person knowledge in face perception. Neuropsychologia. 2007; 45 (1): 163-173.
Haxby JV, Hoffman EA, Gobbini MI,. Human neural systems for face recognition and social communication. Biol Psychiatry. 2002; 51 (1): 59-67.
Gobbini MI, Haxby JV,. Neural response to the visual familiarity of faces. Brain Res Bull. 2006; 71 (1-3): 76-82.
Haxby JV, Hoffman EA, Gobbini MI,. The distributed human neural system for face perception. Trends Cogn Sci. 2000; 4 (6): 223-233.
Cloutier J, Kelley WM, Heatherton TF,. The influence of perceptual and knowledge-based familiarity on the neural substrates of face perception. Soc Neurosci. 2011; 6 (1): 63-75.
Yaoi K, Osaka N, Osaka M,. Is the self special in the dorsomedial prefrontal cortex? An fMRI study. Soc Neurosci. 2009; 4 (5): 455-463.
D'Argembeau A, Ruby P, Collette F, et al. Distinct regions of the medial prefrontal cortex are associated with self-referential processing and perspective taking. J Cogn Neurosci. 2007; 19 (6): 935-944.
Moran JM, Macrae CN, Heatherton TF, Wyland CL, Kelley WM., Neuroanatomical evidence for distinct cognitive and affective components of self. J Cogn Neurosci. 2006; 18 (9): 1586-1594.
Johnson SC, Baxter LC, Wilder LS, Pipe JG, Heiserman JE, Prigatano GP,. Neural correlates of self-reflection. Brain. 2002; 125 (pt 8): 1808-1814.
Mitchell JP, Macrae CN, Banaji MR., Dissociable medial prefrontal contributions to judgments of similar and dissimilar others. Neuron. 2006; 50 (4): 655-663.
Folstein MF, Folstein SE, McHugh PR., €Mini-mental state€. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12 (3): 189-198.
Breen N, Caine D, Coltheart M., Mirrored-self misidentification: two cases of focal onset dementia. Neurocase. 2001; 7 (3): 239-254.
Association AP. DSM-IV, Manuel diagnostique et statistique des troubles mentaux1996. Paris, France: Masson.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM., Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34 (7): 939-944.
Shah NJ, Marshall JC, Zafiris O, et al. The neural correlates of person familiarity. A functional magnetic resonance imaging study with clinical implications. Brain. 2001; 124 (pt 4): 804-815.
Adolphs R., The social brain: neural basis of social knowledge. Annu Rev Psychol. 2009; 60: 693-716.
Ries ML, Jabbar BM, Schmitz TW, et al. Anosognosia in mild cognitive impairment: relationship to activation of cortical midline structures involved in self-appraisal. J Int Neuropsychol Soc. 2007; 13 (3): 450-461.
Rosen HJ, Alcantar O, Rothlind J, et al. Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease. Neuroimage. 2010; 49 (4): 3358-3364.
Zamboni G, Wilcock G,. Lack of awareness of symptoms in people with dementia: the structural and functional basis. Int J Geriatr Psychiatry. 2011; 26 (8): 783-792.
Mimura M,. Memory impairment and awareness of memory deficits in early-stage Alzheimer's disease. Tohoku J Exp Med. 2008; 215 (2): 133-140.
D'Argembeau A, Jedidi H, Balteau E, Bahri M, Phillips C, Salmon E., Valuing one's self: medial prefrontal involvement in epistemic and emotive investments in self-views. Cereb Cortex. 2012; 22 (3): 659-667.
Gusnard DA, Akbudak E, Shulman GL, Raichle ME., Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A. 2001; 98 (7): 4259-4264.
Schmitz TW, Johnson SC., Relevance to self: a brief review and framework of neural systems underlying appraisal. Neurosci Biobehav Rev. 2007; 31 (4): 585-596.
van der Meer L, Costafreda S, Aleman A, David AS., Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neurosci Biobehav Rev. 2010; 34 (6): 935-946.
Meyer ML, Masten CL, Ma Y, et al. Empathy for the social suffering of friends and strangers recruits distinct patterns of brain activation. Soc Cogn Affect Neurosci. 2013; 8 (4): 446-454.
Ellis HD, Lewis MB., Capgras delusion: a window on face recognition. Trends Cogn Sci. 2001; 5 (4): 149-156.
Ellis HD,. Delusions: a suitable case for imaging? Int J Psychophysiol. 2007; 63 (2): 146-151.