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Article (Scientific journals)
Pharma-clinics comment je traite ... une infection par le VIH. III. Les inhibiteurs non nucléosidiques de la transcriptase inverse
Nkoghe, D.; Moutschen, Michel; Leonard, Philippe et al.
1999In Revue Médicale de Liège, 54 (12), p. 909-11
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Abstract :
[en] Non nucleoside reverse transcriptase inhibitors (NNRTI) are a new arm in the treatment of the HIV infection. They inhibit the replication by direct non competitive binding to the enzyme, and do not require phosphorylation. The fast emergence of resistance in monotherapy obliges to use them in a triple association. The 103 mutation confers a cross-resistance. The most common adverse event is rash. Association with nucleoside analogues is additive or even synergistic. They are metabolized by the cytochrome P450. Within a combined therapy, their efficiency is comparable to protease inhibitors, notably in patients with low viral load.
Disciplines :
Immunology & infectious disease
Author, co-author :
Nkoghe, D.
Moutschen, Michel  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Leonard, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Demonty, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Language :
French
Title :
Pharma-clinics comment je traite ... une infection par le VIH. III. Les inhibiteurs non nucléosidiques de la transcriptase inverse
Alternative titles :
[en] Pharma-Clinics. How I Treat ... Hiv Infection. III. Non-Nucleoside Reverse Transcriptase Inhibitors
Publication date :
December 1999
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
54
Issue :
12
Pages :
909-11
Peer reviewed :
Peer reviewed
Available on ORBi :
since 28 April 2013

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