Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappa B through c-FLIP-L expression

Benoit, Valérie; Chariot, Alain; Delacroix, Laurence; Deregowski, Valérie; Jacobs, Nathalie; Merville, Marie-Paule; Bours, Vincent

doi:10.1158/0008-5472.CAN-03-2914

Article (Scientific journals)

Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappa B through c-FLIP-L expression

Benoit, Valérie; Chariot, Alain; Delacroix, Laurence et al.

2004 • In Cancer Research, 64 (8), p. 2684-2691

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/1464

DOI
10.1158/0008-5472.CAN-03-2914

PubMed
15087380

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Keywords :

Adenocarcinoma/enzymology/metabolism/pathology; Anti-Infective Agents/pharmacology; Apoptosis/physiology; Binding Sites; Breast Neoplasms/enzymology/metabolism/pathology; CASP8 and FADD-Like Apoptosis Regulating Protein; Carrier Proteins/metabolism; Caspase 8; Caspases/antagonists & inhibitors/metabolism; Cell Line, Tumor; Cycloheximide/pharmacology; HER-2; Intracellular Signaling Peptides and Proteins; MCF7; NF kappa B; Sulfones; Transcriptional Activation; Tumor Necrosis Factor-alpha/pharmacology

Abstract :

[en] The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads to an early caspase-8-dependent HER-2 cleavage in MCF7 A/Z breast adenocarcinoma cells defective for nuclear factor kappaB (NFkappaB) activation. We show that the antiapoptotic transcription factor NFkappaB counteracts this cleavage through induction of the caspase-8 inhibitor c-FLIP. Our results also demonstrate that this HER-2 cleavage contributes to the TNF-alpha-induced apoptosis pathway because ectopic expression of an uncleavable HER-2 protects NFkappaB-defective cells against TNF-alpha-mediated cell death. Therefore, we propose an original model in which NFkappaB exerts a new antiapoptotic function by counteracting TNF-alpha-triggered cleavage of the HER-2 survival factor.

Research Center/Unit :

Giga-Signal Transduction - ULiège

Disciplines :

Oncology

Author, co-author :

Benoit, Valérie

Chariot, Alain ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Delacroix, Laurence ; Université de Liège - ULiège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén.

Deregowski, Valérie

Jacobs, Nathalie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Merville, Marie-Paule ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Bours, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine

Language :

English

Title :

Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappa B through c-FLIP-L expression

Publication date :

2004

Journal title :

Cancer Research

ISSN :

0008-5472

eISSN :

1538-7445

Publisher :

Amer Assoc Cancer Research, Philadelphia, United States

Volume :

Issue :

Pages :

2684-2691

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
TELEVIE, ARC ULG

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