Resident CD11b(+)Ly6C(-) Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice.

Mesnil, Claire; Sabatel, Catherine; Marichal, Thomas; Toussaint, Marie; Cataldo, Didier; Drion, Pierre; Lekeux, Pierre; Bureau, Fabrice; Desmet, Christophe

doi:10.1371/journal.pone.0053242

Article (Scientific journals)

Resident CD11b(+)Ly6C(-) Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice.

Mesnil, Claire; Sabatel, Catherine; Marichal, Thomas et al.

2012 • In PLoS ONE, 7 (12), p. 53242

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/142864

DOI
10.1371/journal.pone.0053242

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23300898

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Abstract :

[en] Conventional dendritic cells (DCs) are considered to be the prime initiators of airway allergy. Yet, it remains unclear whether specific DC subsets are preferentially involved in allergic airway sensitization. Here, we systematically assessed the respective pro-allergic potential of individually sorted lung DC subsets isolated from house dust mite antigen (HDM)-treated donor mice, following transfer to naive recipients. Transfer of lung CD11c(+)CD11b(+) DCs, but not CD11c(+)CD11b(-)CD103(+) DCs, was sufficient to prime airway allergy. The CD11c(+)CD11b(+) DC subpopulation was composed of CD11c(+)CD11b(+)Ly6C(+) inflammatory monocyte-derived cells, whose numbers increase in the lungs following HDM exposure, and of CD11c(+)CD11b(+)Ly6C(-) DCs, which remain stable. Counterintuitively, only CD11c(+)CD11b(+)Ly6C(-) DCs, and not CD11c(+)CD11b(+)Ly6C(+) DCs, were able to convey antigen to the lymph nodes and induce adaptive T cell responses and subsequent airway allergy. Our results thus support that lung resident non-inflammatory CD11c(+)CD11b(+)Ly6C(-) DCs are the essential inducers of allergic airway sensitization to the common aeroallergen HDM in mice.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Mesnil, Claire ^✱; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie

Sabatel, Catherine ^✱; Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire

Marichal, Thomas ; Université de Liège - ULiège > GIGA-Research

Toussaint, Marie ; Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire

Cataldo, Didier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.

Drion, Pierre ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.

Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie

Bureau, Fabrice ^✱; Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire

Desmet, Christophe ^✱; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Resident CD11b(+)Ly6C(-) Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice.

Publication date :

2012

Journal title :

PLoS ONE

eISSN :

1932-6203

Publisher :

Public Library of Science, San Franscisco, United States - California

Volume :

Issue :

Pages :

e53242

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 14 February 2013

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