[en] "Giant Condylomas" of the cervix are very uncommon, and have not been fully characterized in the English literature. We report 4 cases of cervical giant condyloma seen in our practice. Patients were predominantly young and presented with a cervical lesion producing bleeding or a mass effect. Biopsy/excision revealed a uniformly bland, exophytic squamous epithelial proliferation with viral cytopathic changes and absence of stromal invasion. Human papilloma virus types 6 and 11 were detected in all cases. Follow-up was uneventful without recurrence or spread. Giant condylomas of the cervix as defined in this report signify a benign albeit extensive variant of low-risk human papilloma virus infection. This term is proposed as a specific descriptor for such lesions and should be considered in the setting of any large well-differentiated exophytic cervical squamous lesion in young or immunosuppressed women. The term "giant condyloma of Buschke and Loewenstein" should be discontinued given the lack of specificity.
Disciplines :
Oncology
Author, co-author :
Parra-Herran, Carlos
Herfs, Michael ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Doria, Manuel
Crum, Christopher P.
Nucci, Marisa R.
Language :
English
Title :
Giant Condyloma of the Cervix: An Uncommon Entity Associated With Low-risk Human Papilloma Virus Infection.
Publication date :
2013
Journal title :
American Journal of Surgical Pathology
ISSN :
0147-5185
eISSN :
1532-0979
Publisher :
Lippincott Williams & Wilkins, United States - New York
Steffen C. The men behind the eponym-Abraham Buschke and Ludwig Lowenstein: giant condyloma (Buschke-Lowenstein). Am J Dermatopathol. 2006;28:526-536.
Chu QD, Vezeridis MP, Libbey NP, et al. Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions: analysis of 42 Cases. Dis Colon Rectum. 1994;37:950-957.
Schmauz R, Owor R. Condylomatous tumours of vulva, vagina, and penis. Relation between histological appearance and age. J Clin Pathol. 1980;33:1039-1046.
Hicheri J, Jaber K, Dhaoui MR, et al. Giant condyloma (Buschke-Lowenstein tumor). A case report. Acta Dermatovenerol Alp Panonica Adriat. 2006;15:181-183.
Tan XJ, Wu M, Lang JH. Giant condyloma acuminatum of the vulva. Int J Infect Dis. 2010;14:e455-e456.
Wietfeldt ED, Thiele J. Malignancies of the anal margin and perianal skin. Clin Colon Rectal Surg. 2009;22:127-135.
Crum Christopher P, Nucci Marisa R, Lee Kenneth R. Diagnostic Gynecologic and Obstetric Pathology. 2nd ed. Philadelphia, PA: Elsevier; 2011:201-203.
Trombetta LJ, Place RJ. Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum. 2001;44:1878-1886.
Longacre TA, Kong CS, Welton ML. Diagnostic problems in anal pathology. Adv Anat Pathol. 2008;15:263-278.
Wong WS, Ng CS, Lee CK. Verrucous carcinoma of the cervix. Arch Gynecol Obstet. 1990;247:47-51.
Robboy SJ, Mutter GL, Prat J, et al. Robboy's Pathology of the Female Reproductive Tract. 2nd ed. Philadelphia, PA: Elsevier limited; 2009:244.
Miles PA, Herrera GA, Greenberg H, et al. Condylomas of the uterine cervix initially interpreted as squamous carcinoma: a report of four cases including a lesion resembling the Buschke-Loewenstein giant condyloma. Gynecol Oncol. 1986;24:236-246.
Ward BE, Saleh AM, Williams JV, et al. Papillary immature metaplasia of the cervix: a distinct subset of exophytic cervical condyloma associated with HPV-6/11 nucleic acids. Mod Pathol. 1992;5:391-395.
Trivijitsilp P, Mosher R, Sheets EE, et al. Papillary immature metaplasia (immature condyloma) of the cervix: a clinicopathologic analysis and comparison with papillary squamous carcinoma. Hum Pathol. 1998;29:641-648.
Degefu S, O'Quinn AG, Lacey CG, et al. Verrucous carcinoma of the cervix: a report of two cases and literature review. Gynecol Oncol. 1986;25:37-47.
Frega A, Lukic A, Nobili F, et al. Verrucous carcinoma of the cervix: detection of carcinogenetic human papillomavirus types and their role during follow-up. Anticancer Res. 2007;27(6C):4491-4494.
Cantu de Leon D, Perez Montiel D, Tabarez A, et al. Serous adenocarcinoma of the fallopian tube, associated with verrucous carcinoma of the uterine cervix: a case report of synchronic rare gynecological tumors. World J Surg Oncol. 2009;17:7-20.
Dane B, Dane C, Erginbas M, et al. Verrucous carcinoma of the cervix in a case with uterine prolapse. Ann Diagn Pathol. 2009;13: 344-346.
Pilotti S, Donghi R, D'Amato L, et al. HPV detection and p53 alteration in squamous cell verrucous malignancies of the lower genital tract. Diagn Mol Pathol. 1993;2:248-256.
Gualco M, Bonin S, Foglia G, et al. Morphologic and biologic studies on ten cases of verrucous carcinoma of the vulva supporting the theory of a discrete clinico-pathologic entity. Int J Gynecol Cancer. 2003;13:317-324.
Steffen C. The man behind the eponym. Lauren V. Ackerman and Verrucous Carcinoma of Ackerman. Am J Dermatopathol. 2004;26: 334-341.
Robertson DI, Maung R, Duggan MA. Verrucous carcinoma of the genital tract: is it a distinct entity? Can J Surg. 1993;36:147-151.
Landeyro J, Gutiérrez-Fornés C, Sirvent JJ. Warty (condylomatous) carcinoma of the cervix with extension to the endometrial cavity. Int J Gynaecol Obstet. 2011;112:66-67.
Cho NH, Joo HJ, Ahn HJ, et al. Detection of human papillomavirus in warty carcinoma of the uterine cervix: comparison of immunohistochemistry, in situ hybridization and in situ polymerase chain reaction methods. Pathol Res Pract. 1998;194:713-720.
Randall ME, Andersen WA, Mills SE, et al. Papillary squamous cell carcinoma of the uterine cervix: a clinicopathologic study of nine cases. Int J Gynecol Pathol. 1986;5:1-10.
Koenig C, Turnicky RP, Kankam CF, et al. Papillary squamotransitional cell carcinoma of the cervix: a report of 32 cases. Am J Surg Pathol. 1997;21:915-921.
Nafussi A, Al Yusif R. Papillary squamotransitional cell carcinoma of the uterine cervix: an advanced stage disease despite superficial location: report of two cases and review of the literature. Eur J Gynaecol Oncol. 1998;19:455-457.
