Reference : The neurotrophic receptor TrkB: a drug target in anti-cancer therapy ?
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
The neurotrophic receptor TrkB: a drug target in anti-cancer therapy ?
Desmet, Christophe mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie >]
Peeper, Daniel S. [The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam > Division of Molecular Genetics > > >]
Cellular and Molecular Life Sciences
Yes (verified by ORBi)
[en] Animals ; Antineoplastic Agents/pharmacology ; Humans ; Neoplasms/drug therapy/metabolism ; Receptor, trkB/drug effects ; Signal Transduction
[en] Increasing evidence implies altered signaling through the neurotrophic receptor tyrosine kinase TrkB in promoting tumor formation and metastasis. TrkB, sometimes in conjunction with its primary ligand BDNF, is often overexpressed in a variety of human cancers, ranging from neuroblastomas to pancreatic ductal adenocarcinomas, in which it may allow tumor expansion and contribute to resistance to anti-tumor agents. In vitro, TrkB acts as a potent suppressor of anoikis (detachment-induced apoptosis), which is associated with the acquisition of an aggressive tumorigenic and metastatic phenotype in vivo. In view of its predicted contribution to tumorigenicity and metastasis in humans, TrkB corresponds to a potential drug target, and preclinical models have already been established. The encouraging results of pharmacological Trk inhibitors in tumor xenograft models suggest that TrkB inhibition may represent a promising novel anti-tumor therapeutic strategy. This hypothesis is currently being evaluated in clinical trials. Here, we will discuss the latest developments on TrkB in these contexts as well as highlight some critical questions that remain to be addressed for evaluating TrkB as a therapeutic target in cancer
Researchers ; Professionals

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