Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.

[en] Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy calves, we report confirmation of this effect, demonstrating strong association of early life body weight with PLAG1 genotype. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype. Growth rate per kilogram of body weight, daily feed intake, gross feed efficiency and residual feed intake were not significantly associated with PLAG1 genotype. This study supports the status of PLAG1 as a key regulator of mammalian growth. Further, the data indicate the utility of PLAG1 polymorphisms for the selection of animals to achieve enhanced weight gain or conversely to aid the selection of animals with lower mature body weight and thus lower maintenance energy requirements.

Disciplines :

Genetics & genetic processes

Author, co-author :

Littlejohn, M.

Grala, T.

Sanders, K.

Walker, C.

Waghorn, G.

Macdonald, K.

Coppieters, Wouter ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Spelman, Richard

Hillerton, E.

Davis, S.

Snell, R.

Language :

English

Title :

Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.

Publication date :

October 2012

Journal title :

Animal Genetics

ISSN :

0268-9146

eISSN :

1365-2052

Publisher :

Blackwell, Oxford, United Kingdom

Volume :

Issue :

Pages :

591-4

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 14 January 2013

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