Reference : Development of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxan...
Scientific congresses and symposiums : Poster
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/137728
Development of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor antagonists
English
Bambi Nyanguile, Sylvie-Mireille mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (Bologne)]
Hanson, Julien mailto [Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique >]
Dogné, Jean-Michel []
Pirotte, Bernard mailto [Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique >]
Aug-2012
Yes
Yes
International
19th EuroQSAR
DU 26-30 AOUT 2012
UNIVERSITY OF VIENNA
VIENNE
AUTRICHE
[en] Thromboxane receptor antagonists ; antiplatelet agents ; 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas
[en] A series of novel 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas were synthesized.
The newly synthesized compounds were tested in vitro and ex vivo as thromboxane A2 receptor antagonists.
Some of the test compounds showed potent thromboxane A2 receptor antagonist activity.
Three compounds (7h, 8h and 8e) were identified as leads for further pharmacological and toxicological studies.
LABORATOIRE DE CHIMIE PHARMACEUTIQUE
COOPERATION TECHNIQUE BELGIQUE
DEVELOPPEMENT DE NOUVELLES BENZENES SULFONYLUREES DIVERSEMENTS SUBSTITUEES EN TANT QU ANTAGONISTES DES RECEPTEURS AU THROMBOXANE A2
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/137728

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