Article (Scientific journals)
WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?
Gillet, Nicolas; Carpentier, Alexandre; Barez, Pierre-Yves et al.
2012In Retrovirology, 9 (1), p. 115
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Keywords :
HTLV-1; Tax; HBZ; p53; Wip1; PPM1D; MDM2; DNA damage response; Genomic stress; ATM; Chk2
Abstract :
[en] Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches.
Disciplines :
Oncology
Author, co-author :
Gillet, Nicolas ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Carpentier, Alexandre ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Barez, Pierre-Yves ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
English
Title :
WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?
Publication date :
21 December 2012
Journal title :
Retrovirology
eISSN :
1742-4690
Publisher :
BioMed Central, London, United Kingdom
Volume :
9
Issue :
1
Pages :
115
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 January 2013

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