[en] Alzheimer’s disease (AD) is characterised by altered recollection function, with impaired controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be preserved in the early stages of the disease. This is the first study that directly examines whole brain regional activity during one core aspect of the recollection function: associative controlled episodic retrieval (CER), contrasted to item familiarity in AD patients. Cerebral activity related to associative CER and item familiarity in AD patients and healthy controls (HC) was measured with functional magnetic resonance imaging during a word-pair recognition task to which the process dissociation procedure was applied. Some patients had null CER estimates (AD–), whereas others did show some CER abilities (AD+), although significantly less than HC. In contrast, familiarity estimates were equivalent in the three groups. In AD+, as in controls, associative CER activated the inferior precuneus/posterior cingulate cortex (PCC). However, during associative CER, functional connection between this region and the hippocampus, the inferior parietal and dorsolateral prefrontal cortex (DLPFC) was significantly higher in HC than in AD+. In all three groups, item familiarity was related to activation along the intraparietal sulcus (IPS). In conclusion, whereas the preserved automatic detection of an old item (without retrieval of accurate word association) is related to parietal activation centred on the IPS, the inferior precuneus/PCC supports associative CER ability in AD patients, as in HC. However, AD patients have deficient functional connectivity during associative CER, suggesting that the residual recollection function in these patients might be impoverished by the lack of some recollection-related aspects such as autonoetic quality, episodic details and verification.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Genon, Sarah ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Feyers, Dorothée ; Université de Liège - ULiège > Département Psychologies et cliniques des systèmes humains > Psychologie de la sénescence
Phillips, Christophe ; Université de Liège - ULiège > Centre de recherches du cyclotron
SALMON, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Bastin, Christine ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Item familiarity and controlled associative retrieval in Alzheimer’s disease: An fMRI study.
Publication date :
2012
Event name :
Belgian Brain Council 2012
Event place :
Liège, Belgium
Event date :
27 octobre 2012
Audience :
International
Journal title :
Frontiers in Human Neuroscience
eISSN :
1662-5161
Publisher :
Frontiers Research Foundation, Lausanne, Switzerland
Special issue title :
Front. Hum. Neurosci. Conference Abstract: Belgian Brain Council
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