Letter to the editor (Scientific journals)
Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation
Viatour, Patrick; Merville, Marie-Paule; Bours, Vincent et al.
2005In Trends in Biochemical Sciences, 30 (1), p. 43-52
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Keywords :
NF-kappa B; BCL-3; phosphorylation
Abstract :
[en] Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools.
Research Center/Unit :
GIGA‐R - Giga‐Research - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Viatour, Patrick ;  Université de Liège - ULiège > Chimie médicale
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
Chariot, Alain ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation
Publication date :
January 2005
Journal title :
Trends in Biochemical Sciences
ISSN :
0968-0004
eISSN :
1362-4326
Publisher :
Elsevier Science London, London, United Kingdom
Volume :
30
Issue :
1
Pages :
43-52
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Insight into the oncogenic potential of BCL-3
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Télévie
ULg. ARC - Université de Liège. Actions de Recherche Concertées
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