Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation

[en] Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools.

Research Center/Unit :

GIGA‐R - Giga‐Research - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Viatour, Patrick ; Université de Liège - ULiège > Chimie médicale

Merville, Marie-Paule ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Bours, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine

Chariot, Alain ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Language :

English

Title :

Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation

Publication date :

January 2005

Journal title :

Trends in Biochemical Sciences

ISSN :

0968-0004

eISSN :

0167-7640

Publisher :

Elsevier Science London, London, United Kingdom

Volume :

Issue :

Pages :

43-52

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

Insight into the oncogenic potential of BCL-3

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
Télévie
ULg. ARC - Université de Liège. Actions de Recherche Concertées

Available on ORBi :

since 26 November 2008

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