Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype

tissue engineering; logical modelling; chondrocyte; growth plate; chondrocytes; gene network; differentiation; signalling; endochondral ossification; ossification; genes; model

Abstract :

[en] During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.

Research center :

Biomechanics research unit

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Kerkhofs, Johan ; Université de Liège - ULiège > Form. doct. sc. ingé. (aérosp. & méca - Bologne)

Roberts, Scott J

Luyten, Frank P

Van Oosterwyck, Hans

Geris, Liesbet ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique

Language :

English

Title :

Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype

Publication date :

30 April 2012

Journal title :

PLoS ONE

eISSN :

1932-6203

Publisher :

Public Library of Science, San Franscisco, United States - California

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

FRS.D-10/20

Available on ORBi :

since 14 June 2012

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