Profil

Kerkhofs Johan

Main Referenced Co-authors
Geris, Liesbet  (19)
Van Oosterwyck, Hans (11)
Luyten, Frank P (5)
Germain, Morgan  (4)
Roberts, Scott J (4)
Main Referenced Keywords
Chondrocyte (4); Gene network (4); Modelling (4); Hypertrophy (3); modelling (3);
Main Referenced Unit & Research Centers
Biomechanics Research Unit (3)
BioMech (2)
Biomechanics research unit (1)
Main Referenced Disciplines
Engineering, computing & technology: Multidisciplinary, general & others (21)
Civil engineering (1)

Publications (total 22)

The most downloaded
226 downloads
Kerkhofs, J., Roberts, S. J., Luyten, F. P., Van Oosterwyck, H., & Geris, L. (2012). Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype. PLoS ONE. doi:10.1371/journal.pone.0034729 https://hdl.handle.net/2268/125273

The most cited

23 citations (Scopus®)

Kerkhofs, J., Roberts, S. J., Luyten, F. P., Van Oosterwyck, H., & Geris, L. (2012). Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype. PLoS ONE. doi:10.1371/journal.pone.0034729 https://hdl.handle.net/2268/125273

Khurana, S., Schivo, S., Plass, J. R. M., Mersinis, N., Scholma, J., Kerkhofs, J., Zhong, L., van de Pol, J., Langerak, R., Geris, L., Karperien, M., & Post, J. N. (2021). An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation. Frontiers in Bioengineering and Biotechnology, 9, 732917. doi:10.3389/fbioe.2021.732917
Peer Reviewed verified by ORBi

Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., van de Pol, J., Langerak, R., van Wijnen, A. J., Geris, L., Karperien, M., & Post, J. N. (April 2020). ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease. Cellular Signalling, 68, 109471. doi:10.1016/j.cellsig.2019.109471
Peer Reviewed verified by ORBi

Kerkhofs, J. (2015). Chondrogenic Differentiation in the growth Plate: a Computational Modelling Approach [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/186583

Kerkhofs, J., & Geris, L. (11 June 2015). A semiquantitative framework for gene regulatory networks: increasing the time and quantitative resolution of Boolean networks. PLoS ONE, 10 (6), 0130033. doi:10.1371/journal.pone.0130033
Peer Reviewed verified by ORBi

Kerkhofs, J., Leijten, J., Luyten, F., & Geris, L. (30 April 2015). In silico screening to predict chondrocyte hypertrophy using a semiquantitative gene network model [Poster presentation]. OARSI 2015.

Kerkhofs, J. (18 June 2014). The search for a core functionality network in chondrocyte differentiation using heuristic and genetic algorithms [Paper presentation]. ECTMB 2014.

Germain, M., Kerkhofs, J., & Geris, L. (2014). Simulation and analysis of bistability in osteochondrogenesis [Paper presentation]. ECMTB (European Conference on Mathematical and Theoretical Biology).

Van Schepdael, A., Carlier, A., Ashbourn, J., Nica, I., Kerkhofs, J., & Geris, L. (13 September 2013). Congenital pseudarthrosis of the tibia: a mathematical approach [Paper presentation]. International Conference on Computational Bioengineering.

Kerkhofs, J., Van Oosterwyck, H., & Geris, L. (11 September 2013). A gene regulatory network model evaluating the impact of individual factors in the hypertrophic switch [Paper presentation]. ICCB 2013.

Germain, M., Kerkhofs, J., & Geris, L. (September 2013). Mutual inhibition and bistability: two key elements of the endochondral ossification process [Poster presentation]. ICSB 2013 Copenhagen ( The 14 th International Conference on System Biology).

Kerkhofs, J., Van Oosterwyck, H., & Geris, L. (29 August 2013). A Gene Regulatory Network Model to Assess the Stability of the Cartilage Phenotype [Poster presentation]. ICSB 2013.

Kerkhofs, J., & Van Oosterwyck, H. (17 June 2013). A computational Model to Assess the Contribution of Growth Factors to Phenotype Stability in Chondrocytes [Paper presentation]. TERMIS-EU 2013, Istanbul, Turkey.

Germain, M., Kerkhofs, J., & Geris, L. (2013). MATHEMATICAL MODELING OF ENDOCHONDRAL OSSIFICATION THROUGH MUTUAL INHIBITION AND BISTABILITY [Paper presentation]. ICCB 2013 : V International Conference on Computational Bioengineering.

Germain, M., Kerkhofs, J., & Geris, L. (2013). Modeling the effect of the interaction between BMP and Wnt in osteochondroprogenitor cells [Poster presentation]. BSTE (Belgian Symposium on Tissue Engineering).

Kerkhofs, J., Van Oosterwyck, H., & Geris, L. (18 September 2012). A Dynamic Graph Model of Endochondral Ossification can assess the Importance of Biological Actors in Differentiation [Paper presentation]. 1st Belgian Symposium on Tissue Engineering, Leuven, Belgium.

Kerkhofs, J., Geris, L., Bosmans, B., & Van Oosterwyck, H. (02 July 2012). Bridging the Gap: A Theoretical Model of Mechanotransduction Through ERK Signalling [Paper presentation]. 18th International Congres of the European Society of Biomechanics (ESB), Lisbon, Portugal.

Kerkhofs, J., Roberts, S. J., Luyten, F. P., Van Oosterwyck, H., & Geris, L. (2012). Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype. PLoS ONE. doi:10.1371/journal.pone.0034729
Peer Reviewed verified by ORBi

Kerkhofs, J., Geris, L., Bosmans, B., & Van Oosterwyck, H. (2012). Coupling Cell Mechanics and Intracellular Signalling: Mechanotransduction through ERK. In J. Middleton (Ed.), The Proceedings of the 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. Hotel Berlin, Berlin, Germany, April 7th – 11th, 2012 pages:0-0. ARUP.
Peer reviewed

Kerkhofs, J., Roberst, S. J., Luyten, F. P., Van Oosterwyck, H., & Geris, L. (13 June 2011). A Boolean network approach to developmental engineering [Paper presentation]. TERMIS-EU 2011, Granada, Spain.

Kerkhofs, J., Roberts, S. J., Luyten, F. P., Van Oosterwyck, H., & Geris, L. (26 November 2010). A Boolean network model of the growth plate [Poster presentation]. Belgian Day on Biomedical Engineering, Brussels, Belgium.

Kerkhofs, J., Roberts, S. J., Luyten, F. P., Van Oosterwyck, H., & Geris, L. (10 October 2010). A Boolean network model of the growth plate [Poster presentation]. International Conference on Systems Biology (ICSB 2010), Edinburgh, United Kingdom.

Kerkhofs, J., Roberts, S. J., Van Oosterwyck, H., Luyten, F. P., & Geris, L. (15 September 2010). BMP signalling in growth plate chondrocytes: a Boolean modelling approach [Poster presentation]. 8th international confererence on Bone Morphogenetic Proteins, Leuven, Belgium.

Contact ORBi