[en] Autoimmune pancreatitis has been characterised in 1995, but only a few cases have been published since then, most of them from Japan. This report describes the cases of two Belgian male patients who presented with isolated obstructive jaundice. Radiological imaging studies were highly suggestive of carcinoma of the head of pancreas and both patients underwent uneventful cephalic pancreaticoduodenectomy with portal vein resection. Pathological analysis of the removed tissues suggested an autoimmune process in both cases. Both patients had hyper-gammaglobulinemia and antinuclear antibodies, but failed to show evidence of any other autoimmune disease or cause of chronic pancreatitis. In both cases final diagnosis was autoimmune pancreatitis. Preoperative clinical suspicion of this diagnosis is mandatory and may avoid unnecessary surgery in future cases.
Disciplines :
Surgery Gastroenterology & hepatology Oncology Endocrinology, metabolism & nutrition
Author, co-author :
Servais, Anne-Marie ; Centre Hospitalier Universitaire de Liège - CHU > Administration des patients - Inscription policliniques
Pestieau, Sophie R
Detry, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Honore, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Belaiche, Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Boniver, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Jacquet, Nicolas; Université de Liège - ULiège
Language :
English
Title :
Autoimmune Pancreatitis Mimicking Cancer of the Head of Pancreas: Report of Two Cases
Ito, T., Nakano, I., Koyanagi, S., Miyahara, T., Migita, Y., Ogoshi, K., Sakai, H., Nawata, H., Autoimmune pancreatitis as a new clinical entity. Three cases of autoimmune pancreatitis with effective steroid therapy (1997) Dig. Dis. Sci., 42, pp. 1458-1468
Ectors, N., Maillet, B., Aerts, R., Geboes, K., Donner, A., Borchard, F., Lankisch, P., Kloppel, G., Non-alcoholic duct destructive chronic pancreatitis (1997) Gut, 41, pp. 263-268
Kawaguchi, K., Koike, M., Tsuruta, K., Okamoto, A., Tabata, I., Fujita, N., Lymphoplasmocytic sclerosing pancreatitis with cholangitis : A variant of primary sclerosing cholangitis extensively involving pancreas (1991) Hum. Pathology, 22, pp. 387-395
Yoshida, K., Toki, F., Takeuchi, T., Watanabe, S., Shiratori, K., Hayashi, N., Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis (1995) Dig. Dis. Sciences, 40, pp. 1561-1568
Irie, H., Honda, H., Baba, S., Kuroiwa, T., Yoshimitsu, K., Tajima, T., Jimi, M., Masuda, K., Autoimmune pancreatitis : CT and MR characteristics (1998) Am. J. Roentgenol., 170, pp. 1323-1327
Horiuchi, A., Kawa, S., Akamatsu, T., Aoki, Y., Mukawa, K., Furuya, N., Ochi, Y., Kiyosawa, K., Characteristic pancreatic duct appearance in autoimmune chronic pancreatitis : A case report and review of the Japanese literature (1998) Am. J. Gastroenterol., 93, pp. 260-263
Horiuchi, A., Kaneko, T., Yamamura, N., Nagata, A., Nakamura, T., Akamatsu, T., Mukawa, K., Kiyosawa, K., Autoimmune chronic pancreatitis simulating pancreatic lymphoma (1996) Am. J. Gastroenterol, 91, pp. 2607-2609
Ohana, M., Okazaki, K., Hajiro, K., Kobashi, Y., Multiple pancreatic masses associated with autoimmunity (1998) Am. J. Gastroenterol, 93, pp. 99-102
