Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prevention of peritoneal carcinomatosis

Detroz, Bernard; Laurent, Stanislas; Honore, Pierre; Blaffart, Francine; Limet, Raymond; Meurisse, Michel

doi:10.1080/00015458.2004.11679577

Article (Scientific journals)

Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prevention of peritoneal carcinomatosis

Detroz, Bernard; Laurent, Stanislas; Honore, Pierre et al.

2004 • In Acta Chirurgica Belgica, 104, p. 377-384

Peer Reviewed verified by ORBi

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DOI
10.1080/00015458.2004.11679577

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15469146

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Keywords :

Intraperitoneal chemotherapy; hyperthermia; peritoneal carcinomatosis

Abstract :

[en] Up to now, the prognosis of peritoneal carcinomatosis from GI tract cancers remains very poor. Intraperitoneal hyperthermic chemotherapy has been proposed in the prevention or treatment of peritoneal carcinomatosis. The rationale for this locoregional approach comes from a better knowledge of the physiopathology of the disease. Intraperitoneal chemotherapy achieves high local drug concentration with limited systemic toxicity. It should be performed during or immediately after surgery to be effective towards microscopic residual tumor cells. A synergistic cytotoxic effect has been demonstrated when heat is combined with antineoplastic drugs. Intraperitoneal hyperthermic chemotherapy might not be regarded as the panacée but as a promising step in the management of peritoneal carcinomatosis. Some randomized studies of gastric cancer with macroscopic serosal invasion have suggested the efficacy of hyperthermic intraperitoneal chemotherapy for the prevention of peritoneal carcinomatosis. In patients with peritoneal carcinomatosis, some studies suggest, in selected cases, the positive effect of hyperthermic intraperitoneal chemotherapy on survival, when combined with cytoreductive surgery.

Disciplines :

Surgery

Author, co-author :

Detroz, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

Laurent, Stanislas

Honore, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

Blaffart, Francine ; Centre Hospitalier Universitaire de Liège - CHU > Bloc opératoire chirurgie cardio-vasculaire

Limet, Raymond ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Meurisse, Michel ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

Language :

English

Title :

Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prevention of peritoneal carcinomatosis

Publication date :

2004

Journal title :

Acta Chirurgica Belgica

ISSN :

1784-3421

eISSN :

2577-0160

Publisher :

Acta Medica Belgica, Bruxelles, Belgium

Volume :

104

Pages :

377-384

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 April 2009

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