[en] We report herein the case of a Belgian 76-year-oId woman who developed a hepatic tumour suspected to be a breast cancer metastasis. Radiological imaging and guided biopsies were not contributive. The patient underwent an explorative laparoscopy with frozen sections that did not provide further diagnosis, and an open left bisegmentectomy was performed during the same anaesthesia. Histopathological examination of the hepatic mass showed Echinococcus multilocularis metacestodes, demonstrating alveolar echinococcosis. As our patient denied any travel in foreign countries and has undergone regular abdominal ultrasonographies since her mastectomy, it is highly likely that this alveolar echinococcosis had been contracted in Belgium. If some imported cases may be seldom managed in Belgium, to our knowledge, this case is the first occurrence of alveolar echinococcosis contracted in Belgium. This report, added to the demonstration of E. multilocaris infection of 50% of red foxes in Southern Belgium, and the potential infection of domestic cats and dogs, should attract attention of the medical community on the possible outbreak of endemic alveolar echinococcosis in Belgium, and on the related public health concerns.
Disciplines :
Immunology & infectious disease Surgery Gastroenterology & hepatology
Author, co-author :
Delbecque, Katty ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Detry, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Hayette, Marie-Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
Jeukens, Thierry ; Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie
Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Hardy, N.
Delwaide, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Demonty, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Boverie, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Imagerie médicale
De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Hauwaert, Cécile ; Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie
Honore, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Boniver, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Losson B.J., Mignon B., Brochier B., Bauduin B., Pastoret P. (1997) Infestation du renard roux (Vulpes vulpes) par Echinococcus multilocularis dans la province de Luxembourg (Belgique): résultats de l'enquête effectuée entre, 1993 et 1995. Ann. Med. Vet. 141:149-153.
Van Der Giessen J.W., Rombout Y.B., Franchimont J.H., Limper L.P., Homan W.L. (1999) Detection of Echinococcus multilocularis in foxes in The Netherlands. Vet. Parasitol. 82:49-57.
Petavy A.F., Tenora F., Deblock S., Sergent V. (2000) Echinococcus multilocaris in domestic cats in France. A potential risk factor for alveolar hydatid disease contamination in humans. Vet. Parasitol. 87:151-156.
Petavy A.F., Prost C., Gevrey J., Gilot B., Deblock S. (1988) Infestation naturelle du chat domestique (Felis catus L.) par Echinococcus multilocularis Leuckaert, 1863 (Cestoda): Premier cas en France décelé en zone périurbaine. C. R. Acad. Sci. III 307:553-556.
Losson B.J., Coignoul F. (1997) Larval Echinococcus multilocaris infection in a dog. Vet. Rec. 141:49-50.
Petavy A.F. (1991) Life cycles of Echinococcus multilocularis in relation to human infection. J. Parasitol. 77:133-137.
Batia G. (1997) Echinococcus. Semin. Respir. Infect. 12:171-187.
Playford M.C., Kamiya M. (1992) Immune response to Echinococcus multilocaris infection in the mouse mode: A review. Jpn. J. Vet. Res. 40:113-130.
Gottstein B., Mesarina B., Tanner I., Ammann R.W., Wilson J.F., Eckert J., Lanier A. (1991) Specific cellular and humoral immune responses in patients with different long-term courses of alveolar echinococcosis (infection with Echinococcus multilocaris). Am. J. Trop. Med. Hyg. 45:734-742.
Alkarmi T., Behbehani K. (1989) Echinococcus multilocaris: Inhibition of murine neutrophil and macrophage chemotaxis. Exp. Parasitol. 69:16-22.
Bresson-Hadni S., Vuitton D.A., Lenys D., Liance M., Racadot E., Miguet J.P. (1989) Cellular immune response in Echinococcosis multilocaris infection in human. I. Lymphocyte reactivity to Echinococcus antigens in patients with alveolar echinococcosis. Clin. Exp. Immunol. 78:61-66.
Liance M., Bresson-Hadni S., Vuitton D.A., Lenys D., Carbillet J.P., Houin R. (1992) Effects of cyclosporin A on the course of murine alveolar echinococcosis and on specific cellular and humoral immune response against Echinococcus multilocaris. Int. J. Parasitol. 22:213-228.
Ammam R.W., Eckert J. (1996) Cestodes. Echinococcus. Gastroenterol. Clin. North Am. 25:655-689.
Choji K., Fujita N., Chen M., Spiers A.S., Morita Y., Shinohara M., Nojima T., Irie G. (1992) Alveolar hydatid disease of the liver: Computed tomography and transabdominal ultrasound with histopathological correlation. Clin. Radiol. 46:97-103.
Gottstein B., Schantz P.M., Wilson J.F. (1985) Serologic screening for Echinococcosus multilocularis infections with ELISA. Lancet 8437:1097-1098.
Lanier A.P., Trujillo D.E., Schantz P.M., Wilson J.F., Gottstein B., Mc Mahon B.J. (1987) Comparison of serologic tests for diagnosis and follow up of alveolar hydatid disease. Am. J. Trop. Med. Hyg. 37:609-615.
Balci N.C., Tunaci A., Semelka R.C., Tunaci M., Ozden I., Rozanes I., Acunas B. (2000) Hepatic alveolar echinococcosis: MRI findings. Magn. Reson. Imaging 18:537-541.
Reuter S., Schirrmeister H., Kratzer W., Dreweck C., Reske S.N., Kern P. (1999) Pericystic metabolic activity in alveolar echinococcosis: Assessment and follow-up by positron emission tomography. Clin. Infect. Dis. 29:1157-1163.
Gollackner B., Langle F., Auer H., Maier A., Mittlbock M., Agstner I., Karner J., Langer F., Aspock H., Loidolt H., Rockenschaub S., Steininger R. (2000) Radical surgical therapy of abdominal cystic hydatid disease: Factors of recurrence. World J. Surg. 24:717-721.
Balik A.A., Basoglu M., Celebi F., Open D., Polat K.Y., Atamanalp S.S., Akcay M.N. (1999) Surgical treatment of hydatid disease of the liver: Review of 304 cases. Arch. Surg. 134:166-169.
Ammann R.W., Ilitsch N., Marincek B., Freiburghaus A.U. (1993) Effect of chemotherapy on the larval mass and the long-term course of alveolar echinococcosis. Hepatology 19:735-742.
Ishuzu H., Uchino J., Sato N., Aoki S., Suzuki K., Kuribayashi H. (1997) Effect of albendazole on recurrent and residual alveolar echinococcosis of the liver after surgery. Hepatology 25:528-531.
Bresson-Hadni S., Franza A., Miguet J.P., Vuitton D.A., Lenys D., Monnet E., Landecy G., Paintaud G., Rohmer P., Becker M.C. (1991) Orthotopic liver transplantation for incurable alveolar echinococcosis of the liver: Report of 17 cases. Hepatology 13:1061-1070.
Mboti B., Van de Stadt J., Carlier Y., Peny M., Jacobs F., Bourgeois N., Adler M., Gelin M. (1996) Long-term disease-free survival after liver transplantation for alveolar echinococcosis. Acta Chir. Belg. 96:229-232.
Bresson-Hadni S., Koch S., Beurton I., Vuitton D.A., Bartholomot B., Hrusovsky S., Heyd B., Lenys D., Minello A., Becker M.C., Vanlemmens C., Mantion G.A., Miguet J.P. (1999) Primary disease recurrence after liver transplantation for alveolar echinococcosis: Long-term evaluation in 15 patients. Hepatology 30:857-864.