Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study.

Ogata, Toru; Gregoire, Lucie; Goddard, Katrina A B; Skunca, Magdalena; Tromp, Gerard; Lancaster, Wayne D; Parrado, Antonio R; Lu, Qing; Shibamura, Hidenori; SakalihasanN, Natzi; Limet, Raymond; MacKean, Gerald L; Arthur, Claudette; Sueda, Taijiro; Kuivaniemi, Helena

doi:10.1186/1471-2350-7-67

Article (Scientific journals)

Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study.

Ogata, Toru; Gregoire, Lucie; Goddard, Katrina A B et al.

2006 • In BMC Medical Genetics, 7, p. 67

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https://hdl.handle.net/2268/114286

DOI
10.1186/1471-2350-7-67

PubMed
16879749

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Keywords :

Aortic Aneurysm, Abdominal/genetics; Belgium; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-DQ Antigens/genetics; HLA-DQ alpha-Chains; HLA-DR Antigens/genetics; Haplotypes; Humans; Male; Polymorphism, Genetic

Abstract :

[en] BACKGROUND: Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. METHODS: HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay. RESULTS: We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics). CONCLUSION: This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.

Disciplines :

Surgery

Author, co-author :

Ogata, Toru

Gregoire, Lucie

Goddard, Katrina A B

Skunca, Magdalena

Tromp, Gerard

Lancaster, Wayne D

Parrado, Antonio R

Lu, Qing

Shibamura, Hidenori

SakalihasanN, Natzi ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire

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Language :

English

Title :

Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study.

Publication date :

2006

Journal title :

BMC Medical Genetics

eISSN :

1471-2350

Publisher :

BioMed Central

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Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

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