autoimmunity; chromosome; 6p21.31; genetic association study; riskallele
Abstract :
[en] Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles) in 387 AAA cases and 426 controls. We observed an association with the HLA-DQA1 locus among Belgian males, and found a significant difference in the HLA-DQA1 *0102 allele frequencies between AAA cases and controls. In conclusion, this study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.
Disciplines :
Surgery
Author, co-author :
Tromp, Gerard; Wayne State University School of Medicine (Detroit, MI, USA) > Center for Molecular Medicine and Genetics
Ogata, Toru; Wayne State University School of Medicine (Detroit, MI, USA) > Center for Molecular Medicine and Genetics
Grégoire, Lucie; Wayne State University School of Medicine (Detroit, MI, USA) > Department of Immunology and Microbiology
Goddard, Katrina A. B.; Case Western Reserve University (Cleveland, OH, USA) > Department of Epidemiology and Biostatistics
Skunca, Magdalena; Wayne State University School of Medicine (Detroit, MI, USA) > Center for Molecular Medicine and Genetics
Lancaster, Wayne D.; Wayne State University School of Medicine (Detroit, MI, USA) > Center for Molecular Medicine and Genetics
Parrado, Antonio R.; Case Western Reserve University (Cleveland, OH, USA) > Department of Epidemiology and Biostatistics
Lu, Qing; Case Western Reserve University (Cleveland, OH, USA) > Department of Epidemiology and Biostatistics
Shibamura, Hidenori; Wayne State University School of Medicine (Detroit, MI, USA) > Center for Molecular Medicine and Genetics
SakalihasanN, Natzi ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Limet, Raymond ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Mackean, Gérald L.; Dalhousie University (Halifax, Canada) > Department of Surgery
Arthur, Claudette; Dalhousie University (Halifax, Canada) > Department of Surgery
Sueda, Taijiro; Hiroshima University (Japan) > Department of Surgery. Graduate School of Biomedical Science
Kuivaniemi, Helena; Wayne State University School of Medicine (Detroit, MI, USA) > Department of Surgery
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