Article (Scientific journals)
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Imielinski, Marcin; Baldassano, Robert N; Griffiths, Anne et al.
2009In Nature Genetics, 41 (12), p. 1335-40
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Abstract :
[en] The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Imielinski, Marcin
Baldassano, Robert N
Griffiths, Anne
Russell, Richard K
Annese, Vito
Dubinsky, Marla
Kugathasan, Subra
Bradfield, Jonathan P
Walters, Thomas D
Sleiman, Patrick
Kim, Cecilia E
Muise, Aleixo
Wang, Kai
Glessner, Joseph T
Saeed, Shehzad
Zhang, Haitao
Frackelton, Edward C
Hou, Cuiping
Flory, James H
Otieno, George
Chiavacci, Rosetta M
Grundmeier, Robert
Castro, Massimo
Latiano, Anna
Dallapiccola, Bruno
Stempak, Joanne
Abrams, Debra J
Taylor, Kent
McGovern, Dermot
Heyman, Melvin B
Ferry, George D
Kirschner, Barbara
Lee, Jessica
Essers, Jonah
Grand, Richard
Stephens, Michael
Levine, Arie
Piccoli, David
Van Limbergen, Johan
Cucchiara, Salvatore
Monos, Dimitri S
Guthery, Stephen L
Denson, Lee
Wilson, David C
Grant, Struan F A
Daly, Mark
Silverberg, Mark S
Satsangi, Jack
Hakonarson, Hakon
More authors (39 more) Less
Other collaborator :
Silber, Gary
Wrobel, Iwona
Quiros, Antonio
Barrett, Jeffrey C
Hansoul, Sarah ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Nicolae, Dan L
Cho, Judy H
Duerr, Richard H
Rioux, John D
Brant, Steven R
Barmada, M Michael
Bitton, Alain
Dassopoulos, Themistocles
Datta, Lisa Wu
Green, Todd
Kistner, Emily O
Murtha, Michael T
Regueiro, Miguel D
Rotter, Jerome I
Schumm, L Philip
Steinhart, A Hillary
Targan, Stephan R
Xavier, Ramnik J
Libioulle, Cécile  ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Sandor, Cynthia ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Lathrop, Mark
Belaiche, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Dewit, Olivier
Gut, Ivo
Heath, Simon
Laukens, Debby
Mni, Myriam ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Rutgeerts, Paul
Van Gossum, Andre
Zelenika, Diana
Franchimont, Denis
Hugot, J. P.
Devos, Martine ;  Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie
Vermeire, Severine
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie - Relations académiques et scientifiques (Médecine)
Cardon, Lon R
Anderson, Carl A
Drummond, Hazel
Nimmo, Elaine
Ahmad, Tariq
Prescott, Natalie J
Onnie, Clive M
Fisher, Sheila A
Marchini, Jonathan
Ghori, Jilur
Bumpstead, Suzannah
Gwillam, Rhian
Tremelling, Mark
Deloukas, Panos
Mansfield, John
Jewell, Derek
Mathew, Christopher G
Parkes, Miles
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
More authors (49 more) Less
Language :
English
Title :
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Publication date :
2009
Journal title :
Nature Genetics
ISSN :
1061-4036
eISSN :
1546-1718
Publisher :
Nature Publishing Group, New York, United States - New York
Volume :
41
Issue :
12
Pages :
1335-40
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 February 2010

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