The Solvation Concept Approached By Lipophily

The soivent of biological media is water and interactions between water and solutes are major to explain membrane and protein structures, Therefore, mimicking solvation effects is a challenge to compute native structures of biological molecules. Lipophlly is an, experimental approach of solvation sinca it measures the parItion of a solute between two solvents, the reterence being water. In the last decade, different attempts were made to extract parameters from lipophily that will enable to describe soivation of complex molecules. We discuss here some analysis made with the atomie transfer energy and the atomic aurface parameter in the study of protein folding and protein Insertion in membranes.