Reference : Intestinal Growth and Pathology og Giardia duodenalis assemblage subtype AI, AII, B e...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Intestinal Growth and Pathology og Giardia duodenalis assemblage subtype AI, AII, B end E in the gerbil model
Bénéré, Ely [Universiteit Antwerpen - UA > > > >]
Van Assche, Tim [Universiteit Antwerpen - UA > > > >]
Van Ginneken, Chris [Universiteit Antwerpen - UA > > > >]
Peulen, Olivier mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Cos, Paul [Universiteit Antwerpen - UA > > > >]
Maes, Louis [Universiteit Antwerpen - UA > > > >]
Cambridge University Press
Yes (verified by ORBi)
New York
[en] assemblage subtypes AI, AII, B and E ; growth dynamics ; virulence
[en] This study investigated the significance of the genetic differences between assemblages A, B and E on intestinal growth and virulence. Intestinal growth and virulence were studied in 2 laboratory (AI: WB and B: GS/M-83-H7) and 6 field isolates of assemblage subtype AI, AII, B and EIII. Intestinal trophozoite burdens, body weight and faecal consistency were monitored until day 29 post-infection (p.i.), morphological (mucosal architecture and inflammation) and functional (disaccharidase and alkaline phosphatase enzyme activity) damage to the small intestine were evaluated on days 7 and 18 p.i. The assemblage subtypes AI and B were more infectious and produced higher trophozoite loads for a longer period compared to the subtypes AII and EIII. The body weight of infected gerbils was significantly reduced compared to uninfected controls, but did not differ between the assemblage subtypes. Consistent softening of the faeces was only observed with assemblage B. Assemblage B next to assemblage subtype AI elicited relatively higher pathogenicity, characterized by more extensive damage to mucosal architecture, decreased brush-border enzyme function and infiltration of inflammatory cells. Assemblage EIII and AII isolates showed relatively low virulence. The Giardia assemblage subtypes exhibit different levels of growth and virulence in the gerbil model.

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