A pauci-symptomatic case of documented Hantavirus (Puumala) infection in a patient under anti-TNF treatment.

Adolescent; Antibodies, Viral/blood; Crohn Disease/drug therapy; Hantavirus/immunology; Hantavirus Infections/diagnosis/pathology; Humans; Immunologic Factors/therapeutic use; Male; Serologic Tests; Tumor Necrosis Factor-alpha/antagonists & inhibitors

Abstract :

[en] We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying sign or symptom or paraclinical abnormality despite extensive work-up performed in the context of his immunocompromised state. Symptoms disappeared after 10 days and a diagnosis of Puumala infection was made retrospectively on a serological basis. The case illustrates that anti-TNF treatment does not worsen the course of Puumala infection and could even be associated with a milder clinical picture.

Disciplines :

General & internal medicine

Author, co-author :

Moutschen, Pierre

Bourhaba, Maryam ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

FRIPPIAT, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale

GIOT, Jean-Baptiste ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale

MEURIS, Christelle ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale

Leonard, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale

Moutschen, Michel ; Université de Liège - ULiège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén.

Language :

English

Title :

A pauci-symptomatic case of documented Hantavirus (Puumala) infection in a patient under anti-TNF treatment.

Publication date :

2011

Journal title :

Journal of Clinical Virology

ISSN :

1386-6532

eISSN :

1873-5967

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

Issue :

Pages :

247-8

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 15 December 2011

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