The HTLV-1 Tax interactome.

Cell Cycle Proteins/genetics/metabolism; Gene Products, tax/chemistry/genetics/metabolism; HTLV-I Infections/metabolism/physiopathology/virology; Host-Pathogen Interactions; Human T-lymphotropic virus 1/chemistry/enzymology/genetics; Humans; Nuclear Pore Complex Proteins/genetics/metabolism; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Transcription Factors/genetics/metabolism; Transcriptional Activation

Abstract :

[en] The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

Disciplines :

Oncology

Author, co-author :

Boxus, Mathieu ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Twizere, Jean-Claude ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Legros, Sebastien

Dewulf, Jean-François

Kettmann, Richard ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Willems, Luc ; Université de Liège - ULiège > GIGA-Research

Language :

English

Title :

The HTLV-1 Tax interactome.

Publication date :

2008

Journal title :

Retrovirology

eISSN :

1742-4690

Publisher :

BioMed Central, London, United Kingdom

Volume :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 April 2009

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Scopus citations^®

229

Scopus citations^®
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215

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188

OpenAlex citations

246

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