The HTLV-1 Tax interactome.

Cell Cycle Proteins/genetics/metabolism; Gene Products, tax/chemistry/genetics/metabolism; HTLV-I Infections/metabolism/physiopathology/virology; Host-Pathogen Interactions; Human T-lymphotropic virus 1/chemistry/enzymology/genetics; Humans; Nuclear Pore Complex Proteins/genetics/metabolism; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Transcription Factors/genetics/metabolism; Transcriptional Activation

Abstract :

[en] The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

Disciplines :

Oncology

Author, co-author :

Boxus, Mathieu ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Twizere, Jean-Claude ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Legros, Sebastien

Dewulf, Jean-François

Kettmann, Richard ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Willems, Luc ; Université de Liège - ULiège > GIGA-Research

Language :

English

Title :

The HTLV-1 Tax interactome.

Publication date :

2008

Journal title :

Retrovirology

eISSN :

1742-4690

Publisher :

BioMed Central, London, United Kingdom

Volume :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 April 2009

Statistics

Number of views

131 (23 by ULiège)

Number of downloads

2 (1 by ULiège)

More statistics

Scopus citations^®

221

Scopus citations^®
without self-citations

208

OpenCitations

188

OpenAlex citations

242

Bibliography

Poiesz BJ Ruscetti FW Gazdar AF Bunn PA Minna JD Gallo RC Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma Proc Natl Acad Sci U S A 1980, 77:7415-7419. 6261256
Kalyanaraman VS Narayanan R Feorino P Ramsey RB Palmer EL Chorba T McDougal S Getchell JP Holloway B Harrison AK. Isolation and characterization of a human T cell leukemia virus type II from a hemophilia-A patient with pancytopenia EMBO J 1985, 4:1455-1460. 2992932
Calattini S Chevalier SA Duprez R Bassot S Froment A Mahieux R Gessain A Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa Retrovirology 2005, 2:30. 15882466
Wolfe ND Heneine W Carr JK Garcia AD Shanmugam V Tamoufe U Torimiro JN Prosser AT Lebreton M Mpoudi-Ngole E McCutchan FE Birx DL Folks TM Burke DS Switzer WM Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters Proc Natl Acad Sci U S A 2005, 102:7994-7999. 15911757
Feuer G Green PL Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 Oncogene 2005, 24:5996-6004. 16155606
Araujo A Hall WW Human T-lymphotropic virus type II and neurological disease Ann Neurol 2004, 56:10-19. 15236397
Liegeois F Lafay B Switzer WM Locatelli S Mpoudi-Ngole E Loul S Heneine W Delaporte E Peeters M Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in Cameroon Virology 2008, 371:405-417. 17976676
Gillet N Florins A Boxus M Burteau C Nigro A Vandermeers F Balon H Bouzar AB Defoiche J Burny A Reichert M Kettmann R Willems L Mechanisms of leukemogenesis induced by bovine leukemia virus: Prospects for novel anti-retroviral therapies in human Retrovirology 2007, 4:18. 17362524
Gaudray G Gachon F Basbous J Biard-Piechaczyk M Devaux C Mesnard JM The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription J Virol 2002, 76:12813-12822. 12438606
Cavanagh MH Landry S Audet B Arpin-Andre C Hivin P Pare ME Thete J Wattel E Marriott SJ Mesnard JM Barbeau B HTLV-I antisense transcripts initiating in the 3′LTR are alternatively spliced and polyadenylated Retrovirology 2006, 3:15. 16512901
Matsuoka M Jeang KT Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation Nat Rev Cancer 2007, 7:270-280. 17384582
Hivin P Basbous J Raymond F Henaff D Arpin-Andre C Robert-Hebmann V Barbeau B Mesnard JM The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies Retrovirology 2007, 4:14. 17306025
Kuhlmann AS Villaudy J Gazzolo L Castellazzi M Mesnard JM Duc DM HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT) Retrovirology 2007, 4:92. 18078517
Clerc I Polakowski N Andre-Arpin C Cook P Barbeau B Mesnard JM Lemasson I An interaction between the HTLV-1 bZIP factor (HBZ) and the KIX domain of p300/CBP contributes to the downregulation of Tax-dependent viral transcription by HBZ J Biol Chem; 2008. 18599479
Usui T Yanagihara K Tsukasaki K Murata K Hasegawa H Yamada Y Kamihira S Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells Retrovirology 2008, 5:34. 18426605
Grassmann R Aboud M Jeang KT Molecular mechanisms of cellular transformation by HTLV-1 Tax Oncogene 2005, 24:5976-5985. 16155604
Nerenberg M Hinrichs SH Reynolds RK Khoury G Jay G The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice Science 1987, 237:1324-1329. 2888190
Pozzatti R Vogel J Jay G The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells Mol Cell Biol 1990, 10:413-417. 2403646
Lee TI Young RA Transcription of eukaryotic protein-coding genes Annu Rev Genet 2000, 34:77-137. 11092823
Smale ST Kadonaga JT The RNA polymerase II core promoter Annu Rev Biochem 2003, 72:449-479. 12651739
Ng PW Iha H Iwanaga Y Bittner M Chen Y Jiang Y Gooden G Trent JM Meltzer P Jeang KT Zeichner SL Genome-wide expression changes induced by HTLV-1 Tax: Evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation Oncogene 2001, 20:4484-4496. 11494144
Felber BK Paskalis H Kleinman-Ewing C Wong-Staal F Pavlakis GN The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats Science 1985, 229:675-679. 2992082
Brady J Jeang KT Duvall J Khoury G Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat J Virol 1987, 61:2175-2181. 3035218
Jeang KT Boros I Brady J Radonovich M Khoury G Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence J Virol 1988, 62:4499-4509. 3263510
Giam CZ Xu YL HTLV-I tax gene product activates transcription via pre-existing cellular factors and cAMP responsive element J Biol Chem 1989, 264:15236-15241. 2768259
Zhao LJ Giam CZ Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction Proc Natl Acad Sci U S A 1992, 89:7070-7074. 1386673
Low KG Chu HM Schwartz PM Daniels GM Melner MH Comb MJ Novel interactions between human T-cell leukemia virus type I Tax and activating transcription factor 3 at a cyclic AMP-responsive element Mol Cell Biol 1994, 14:4958-4974. 8007991
Bantignies F Rousset R Desbois C Jalinot P Genetic characterization of transactivation of the human T-cell leukemia virus type 1 promoter: Binding of Tax to Tax-responsive element 1 is mediated by the cyclic AMP-responsive members of the CREB/ATF family of transcription factors Mol Cell Biol 1996, 16:2174-2182. 8628284
Reddy TR Tang H Li X Wong-Staal F Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4) Oncogene 1997, 14:2785-2792. 9190894
Franklin AA Kubik MF Uittenbogaard MN Brauweiler A Utaisincharoen P Matthews MA Dynan WS Hoeffler JP Nyborg JK Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB) J Biol Chem 1993, 268:21225-21231. 8407959
Ku SC Lee J Lau J Gurumurthy M Ng R Lwa SH Lee J Klase Z Kashanchi F Chao SH XBP-1, a novel human T-lymphotropic virus type 1 (HTLV-1) tax binding protein, activates HTLV-1 basal and tax-activated transcription J Virol 2008, 82:4343-4353. 18287238
Hai T Hartman MG The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis Gene 2001, 273:1-11. 11483355
Perini G Wagner S Green MR Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax Nature 1995, 376:602-605. 7637811
Wagner S Green MR HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization Science 1993, 262:395-399. 8211160
Anderson MG Dynan WS Quantitative studies of the effect of HTLV-I Tax protein on CREB protein--DNA binding Nucleic Acids Res 1994, 22:3194-3201. 8065935
Yin MJ Gaynor RB HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity J Mol Biol 1996, 264:20-31. 8950264
Kimzey AL Dynan WS Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking J Biol Chem 1998, 273:13768-13775. 9593719
Lundblad JR Kwok RP Laurance ME Huang MS Richards JP Brennan RG Goodman RH The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove J Biol Chem 1998, 273:19251-19259. 9668114
Jin DY Jeang KT HTLV-I Tax self-association in optimal trans-activation function Nucleic Acids Res 1997, 25:379-387. 9016568
Tie F Adya N Greene WC Giam CZ Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat J Virol 1996, 70:8368-8374. 8970957
Lemasson I Polakowski NJ Laybourn PJ Nyborg JK Transcription factor binding and histone modifications on the integrated proviral promoter in human T-cell leukemia virus-I-infected T-cells J Biol Chem 2002, 277:49459-49465. 12386157
Forgacs E Gupta SK Kerry JA Semmes OJ The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription J Virol 2005, 79:6932-6939. 15890932
Koga H Ohshima T Shimotohno K Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3 J Biol Chem 2004, 279:52978-52983. 15466468
Siu YT Chin KT Siu KL Yee Wai CE Jeang KT Jin DY TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats J Virol 2006, 80:7052-7059. 16809310
Persengiev SP Green MR The role of ATF/CREB family members in cell growth, survival and apoptosis Apoptosis 2003, 8:225-228. 12766482
Akagi T Ono H Nyunoya H Shimotohno K Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes Oncogene 1997, 14:2071-2078. 9160887
Robek MD Ratner L Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone J Virol 1999, 73:4856-4865. 10233947
Rosin O Koch C Schmitt I Semmes OJ Jeang KT Grassmann R A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes J Biol Chem 1998, 273:6698-6703. 9506967
Matsumoto K Shibata H Fujisawa JI Inoue H Hakura A Tsukahara T Fujii M Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways J Virol 1997, 71:4445-4451. 9151835
de la Fuente C Gupta MV Klase Z Strouss K Cahan P McCaffery T Galante A Soteropoulos P Pumfery A Fujii M Kashanchi F Involvement of HTLV-I Tax and CREB in aneuploidy: A bioinformatics approach Retrovirology 2006, 3:43. 16822311
Dodon MD Li Z Hamaia S Gazzolo L Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells J Gen Virol 2004, 85:1921-1932. 15218177
Alexandre C Verrier B Four regulatory elements in the human c-fos promoter mediate transactivation by HTLV-1 Tax protein Oncogene 1991, 6:543-551. 1827666
Kibler KV Jeang KT CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein J Virol 2001, 75:2161-2173. 11160720
Mulloy JC Kislyakova T Cereseto A Casareto L LoMonico A Fullen J Lorenzi MV Cara A Nicot C Giam C Franchini G Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain J Virol 1998, 72:8852-8860. 9765430
Nicot C Opavsky R Mahieux R Johnson JM Brady JN Wolff L Franchini G Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells AIDS Res Hum Retroviruses 2000, 16:1629-1632. 11080802
Fujii M Niki T Mori T Matsuda T Matsui M Nomura N Seiki M HTLV-1 Tax induces expression of various immediate early serum responsive genes Oncogene 1991, 6:1023-1029. 1906155
Fujii M Iwai K Oie M Fukushi M Yamamoto N Kannagi M Mori N Activation of oncogenic transcription factor AP-1 in T cells infected with human T cell leukemia virus type 1 AIDS Res Hum Retroviruses 2000, 16:1603-1606. 11080798
Alexandre C Charnay P Verrier B Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements Oncogene 1991, 6:1851-1857. 1833716
Fujii M Tsuchiya H Chuhjo T Akizawa T Seiki M Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes Genes Dev 1992, 6:2066-2076. 1427072
Fujii M Chuhjo T Minamino T Masaaki N Miyamoto K Seiki M Identification of the Tax interaction region of serum response factor that mediates the aberrant induction of immediate early genes through CArG boxes by HTLV-I Tax Oncogene 1995, 11:7-14. 7624133
Suzuki T Hirai H Fujisawa J Fujita T Yoshida M A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kappa B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappa B site and CArG box Oncogene 1993, 8:2391-2397. 8361755
Dittmer J Pise-Masison CA Clemens KE Choi KS Brady JN Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter J Biol Chem 1997, 272:4953-4958. 9030555
Shuh M Derse D Ternary complex factors and cofactors are essential for human T-cell leukemia virus type 1 tax transactivation of the serum response element J Virol 2000, 74:11394-11397. 11070040
Winter HY Marriott SJ Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection J Virol 2007, 81:6089-6098. 17376895
Inoue J Seiki M Taniguchi T Tsuru S Yoshida M Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1 EMBO J 1986, 5:2883-2888. 3024966
Cross SL Feinberg MB Wolf JB Holbrook NJ Wong-Staal F Leonard WJ Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I Cell 1987, 49:47-56. 3030566
Maruyama M Shibuya H Harada H Hatakeyama M Seiki M Fujita T Inoue J Yoshida M Taniguchi T Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering Cell 1987, 48:343-350. 3026643
Siekevitz M Feinberg MB Holbrook N Wong-Staal F Greene WC Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I Proc Natl Acad Sci U S A 1987, 84:5389-5393. 3037548
Ballard DW Bohnlein E Lowenthal JW Wano Y Franza BR Greene WC HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene Science 1988, 241:1652-1655. 2843985
Crenon I Beraud C Simard P Montagne J Veschambre P Jalinot P The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene Oncogene 1993, 8:867-875. 8455941
Siebenlist U Franzoso G Brown K Structure, regulation and function of NF-kappa B Annu Rev Cell Biol 1994, 10:405-455. 7888182
Perkins ND Integrating cell-signalling pathways with NF-kappaB and IKK function Nat Rev Mol Cell Biol 2007, 8:49-62. 17183360
Karin M Ben Neriah Y Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity Annu Rev Immunol 2000, 18:621-663. 10837071
Murakami T Hirai H Suzuki T Fujisawa J Yoshida M HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100 Virology 1995, 206:1066-1074. 7856081
Suzuki T Hirai H Yoshida M Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription Oncogene 1994, 9:3099-3105. 7936632
Lamsoul I Lodewick J Lebrun S Brasseur R Burny A Gaynor RB Bex F Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein Mol Cell Biol 2005, 25:10391-10406. 16287853
Azran I Jeang KT Aboud M High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-kappaB-CBP ternary complex in the cytoplasm Oncogene 2005, 24:4521-4530. 15806143
Petropoulos L Lin R Hiscott J Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein Virology 1996, 225:52-64. 8918533
Bex F Yin MJ Burny A Gaynor RB Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300 Mol Cell Biol 1998, 18:2392-2405. 9528808
Bex F Gaynor RB Regulation of gene expression by HTLV-I Tax protein Methods 1998, 16:83-94. 9774518
Tsukada J Misago M Serino Y Ogawa R Murakami S Nakanishi M Tonai S Kominato Y Morimoto I Auron PE Eto S Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1 Blood 1997, 90:3142-3153. 9376596
Pise-Masison CA Dittmer J Clemens KE Brady JN Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y Mol Cell Biol 1997, 17:1236-1243. 9032250
Hivin P Gaudray G Devaux C Mesnard JM Interaction between C/EBPbeta and Tax down-regulates human T-cell leukemia virus type I transcription Virology 2004, 318:556-565. 14972524
Nerlov C The C/EBP family of transcription factors: A paradigm for interaction between gene expression and proliferation control Trends Cell Biol 2007, 17:318-324. 17658261
Trejo SR Fahl WE Ratner L The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1 J Biol Chem 1997, 272:27411-27421. 9341193
Richard V Lairmore MD Green PL Feuer G Erbe RS Albrecht B D'Souza C Keller ET Dai J Rosol TJ Humoral hypercalcemia of malignancy: Severe combined immunodeficient/beige mouse model of adult T-cell lymphoma independent of human T-cell lymphotropic virus type-1 tax expression Am J Pathol 2001, 158:2219-2228. 11395400
Nadella MV Shu ST Dirksen WP Thudi NK Nadella KS Fernandez SA Lairmore MD Green PL Rosol TJ Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation Retrovirology 2008, 5:46. 18541021
Moriuchi M Moriuchi H Fauci AS HTLV type I Tax activation of the CXCR4 promoter by association with nuclear respiratory factor 1 AIDS Res Hum Retroviruses 1999, 15:821-827. 10381170
Twizere JC Lefebvre L Collete D Debacq C Urbain P Heremans H Jauniaux JC Burny A Willems L Kettmann R The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity J Biol Chem 2005, 280:29804-29811. 15970589
Caron C Rousset R Beraud C Moncollin V Egly JM Jalinot P Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP EMBO J 1993, 12:4269-4278. 8223437
Caron C Mengus G Dubrowskaya V Roisin A Davidson I Jalinot P Human TAF(II)28 interacts with the human T cell leukemia virus type I Tax transactivator and promotes its transcriptional activity Proc Natl Acad Sci U S A 1997, 94:3662-3667. 9108034
Clemens KE Piras G Radonovich MF Choi KS Duvall JF DeJong J Roeder R Brady JN Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA Mol Cell Biol 1996, 16:4656-4664. 8756622
Ching YP Chun AC Chin KT Zhang ZQ Jeang KT Jin DY Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex Retrovirology 2004, 1:18. 15285791
Peterson CL Chromatin remodeling enzymes: Taming the machines. Third in review series on chromatin dynamics EMBO Rep 2002, 3:319-322. 11943761
Peterson CL Chromatin remodeling: Nucleosomes bulging at the seams Curr Biol 2002, 12:R245-R247. 11937040
Ruthenburg AJ Li H Patel DJ Allis CD Multivalent engagement of chromatin modifications by linked binding modules Nat Rev Mol Cell Biol 2007, 8:983-994. 18037899
Bogenberger JM Laybourn PJ Human T Lymphotropic Virus Type 1 protein Tax reduces histone levels Retrovirology 2008, 5:9. 18237376
Giebler HA Loring JE van Orden K Colgin MA Garrus JE Escudero KW Brauweiler A Nyborg JK Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of Tax transactivation Mol Cell Biol 1997, 17:5156-5164. 9271393
Lenzmeier BA Giebler HA Nyborg JK Human T-cell leukemia virus type 1 Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter Mol Cell Biol 1998, 18:721-731. 9447968
Kwok RP Laurance ME Lundblad JR Goldman PS Shih H Connor LM Marriott SJ Goodman RH Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP Nature 1996, 380:642-646. 8602268
Jiang H Lu H Schiltz RL Pise-Masison CA Ogryzko VV Nakatani Y Brady JN PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner Mol Cell Biol 1999, 19:8136-8145. 10567539
Harrod R Kuo YL Tang Y Yao Y Vassilev A Nakatani Y Giam CZ p300 and p300/ cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex J Biol Chem 2000, 275:11852-11857. 10766811
Okada M Jeang KT Differential requirements for activation of integrated and transiently transfected human T-cell leukemia virus type 1 long terminal repeat J Virol 2002, 76:12564-12573. 12438582
Georges SA Kraus WL Luger K Nyborg JK Laybourn PJ p300-mediated tax transactivation from recombinant chromatin: Histone tail deletion mimics coactivator function Mol Cell Biol 2002, 22:127-137. 11739728
Lu H Pise-Masison CA Fletcher TM Schiltz RL Nagaich AK Radonovich M Hager G Cole PA Brady JN Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template Mol Cell Biol 2002, 22:4450-4462. 12052856
Parker D Ferreri K Nakajima T LaMorte VJ Evans R Koerber SC Hoeger C Montminy MR Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism Mol Cell Biol 1996, 16:694-703. 8552098
Radhakrishnan I Perez-Alvarado GC Parker D Dyson HJ Montminy MR Wright PE Solution structure of the KIX domain of CBP bound to the transactivation dOmain of CREB: A model for activator:coactivator interactions Cell 1997, 91:741-752. 9413984
Johannessen M Delghandi MP Moens U What turns CREB on? Cell Signal 2004, 16:1211-1227. 15337521
Trevisan R Daprai L Acquasaliente L Ciminale V Chieco-Bianchi L Saggioro D Relevance of CREB phosphorylation in the anti-apoptotic function of human T-lymphotropic virus type 1 tax protein in serum-deprived murine fibroblasts Exp Cell Res 2004, 299:57-67. 15302573
Kim YM Ramirez JA Mick JE Giebler HA Yan JP Nyborg JK Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation J Biol Chem 2007, 282:18750-18757. 17449469
Ramirez JA Nyborg JK Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300 J Mol Biol 2007, 372:958-969. 17707401
Geiger TR Sharma N Kim YM Nyborg JK The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB Mol Cell Biol 2008, 28:1383-1392. 18070920
Livengood JA Scoggin KE van Orden K McBryant SJ Edayathumangalam RS Laybourn PJ Nyborg JK p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300 J Biol Chem 2002, 277:9054-9061. 11782467
Riou P Bex F Gazzolo L The human T cell leukemia/lymphotropic virus type 1 Tax protein represses MyoD-dependent transcription by inhibiting MyoD-binding to the KIX domain of p300. A potential mechanism for Tax-mediated repression of the transcriptional activity of basic helix-loop-helix factors J Biol Chem 2000, 275:10551-10560. 10744749
Yoshida M Multiple viral strategies of HTLV-1 for dysregulation of cell growth control Annu Rev Immunol 2001, 19:475-496. 11244044
Zhang J Yamada O Kawagishi K Araki H Yamaoka S Hattori T Shimotohno K Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300 Virology; 2008. Epub ahead of print
Tabakin-Fix Y Azran I Schavinky-Khrapunsky Y Levy O Aboud M Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications Carcinogenesis 2006, 27:673-681. 16308315
Lemasson I Polakowski NJ Laybourn PJ Nyborg JK Transcription regulatory complexes bind the human T-cell leukemia virus 5′ and 3′ long terminal repeats to control gene expression Mol Cell Biol 2004, 24:6117-6126. 15226416
Ego T Ariumi Y Shimotohno K The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression Oncogene 2002, 21:7241-7246. 12370815
Lu H Pise-Masison CA Linton R Park HU Schiltz RL Sartorelli V Brady JN Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat J Virol 2004, 78:6735-6743. 15194748
Cheng J Kydd AR Nakase K Noonan KM Murakami A Tao H Dwyer M Xu C Zhu Q Marasco WA Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein Blood 2007, 110:2110-2120. 17540846
Ariumi Y Ego T Kaida A Matsumoto M Pandolfi PP Shimotohno K Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein Oncogene 2003, 22:1611-1619. 12642864
Ego T Tanaka Y Shimotohno K Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR Oncogene 2005, 24:1914-1923. 15674330
Kamoi K Yamamoto K Misawa A Miyake A Ishida T Tanaka Y Mochizuki M Watanabe T SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR Retrovirology 2006, 3:5. 16409643
Gray SG Iglesias AH Lizcano F Villanueva R Camelo S Jingu H Teh BT Koibuchi N Chin WW Kokkotou E Dangond F Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein J Biol Chem 2005, 280:28507-28518. 15927959
Kouzarides T Chromatin modifications and their function Cell 2007, 128:693-705. 17320507
Jeong SJ Lu H Cho WK Park HU Pise-Masison C Brady JN Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax J Virol 2006, 80:10036-10044. 17005681
Li B Carey M Workman JL The role of chromatin during transcription Cell 2007, 128:707-719. 17320508
Wang W The SWI/SNF family of ATP-dependent chromatin remodelers: Similar mechanisms for diverse functions Curr Top Microbiol Immunol 2003, 274:143-169. 12596907
Wu K Bottazzi ME de la FC Deng L Gitlin SD Maddukuri A Dadgar S Li H Vertes A Pumfery A Kashanchi F Protein profile of tax-associated complexes J Biol Chem 2004, 279:495-508. 14530271
Zhang L Liu M Merling R Giam CZ Versatile reporter systems show that transactivation by human T-cell leukemia virus type 1 Tax occurs independently of chromatin remodeling factor BRG1 J Virol 2006, 80:7459-7468. 16840326
Lemasson I Polakowski NJ Laybourn PJ Nyborg JK Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1 J Biol Chem 2006, 281:13075-13082. 16547351
Workman JL Nucleosome displacement in transcription Genes Dev 2006, 20:2009-2017. 16882978
Gavin I Horn PJ Peterson CL SWI/SNF chromatin remodeling requires changes in DNA topology Mol Cell 2001, 7:97-104. 11172715
Suzuki T Uchida-Toita M Andoh T Yoshida M HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity Virology 2000, 270:291-298. 10792988
Peterlin BM Price DH Controlling the elongation phase of transcription with P-TEFb Mol Cell 2006, 23:297-305. 16885020
Price DH P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II Mol Cell Biol 2000, 20:2629-2634. 10733565
Cho WK Zhou M Jang MK Huang K Jeong SJ Ozato K Brady JN Modulation of the Brd4/P-TEFb interaction by the human T-lymphotropic virus type 1 tax protein J Virol 2007, 81:11179-11186. 17686863
Zhou M Lu H Park H Wilson-Chiru J Linton R Brady JN Tax interacts with P-TEFb in a novel manner to stimulate human T-lymphotropic virus type 1 transcription J Virol 2006, 80:4781-4791. 16641271
Lin S Coutinho-Mansfield G Wang D Pandit S Fu XD The splicing factor SC35 has an active role in transcriptional elongation Nat Struct Mol Biol 2008, 15:819-826. 18641664
Semmes OJ Jeang KT Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles J Virol 1996, 70:6347-6357. 8709263
Gronemeyer H Gustafsson JA Laudet V Principles for modulation of the nuclear receptor superfamily Nat Rev Drug Discov 2004, 3:950-964. 15520817
Doucas V Evans RM Human T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signaling Proc Natl Acad Sci U S A 1999, 96:2633-2638. 10077562
Chin KT Chun AC Ching YP Jeang KT Jin DY Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1 Cancer Res 2007, 67:1072-1081. 17283140
Blackshear PJ Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover Biochem Soc Trans 2002, 30:945-952. 12440952
Anderson P Kedersha N RNA granules J Cell Biol 2006, 172:803-808. 16520386
Bakheet T Williams BR Khabar KS ARED 3.0: The large and diverse AU-rich transcriptome Nucleic Acids Res 2006, 34:D111-D114. 16381826
Twizere JC Kruys V Lefebvre L Vanderplasschen A Collete D Debacq C Lai WS Jauniaux JC Bernstein LR Semmes OJ Burny A Blackshear PJ Kettmann R Willems L Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression J Natl Cancer Inst 2003, 95:1846-1859. 14679154
Desbois C Rousset R Bantignies F Jalinot P Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein Science 1996, 273:951-953. 8688078
Donzeau M Winnacker EL Meisterernst M Specific repression of Tax trans-activation by TAR RNA-binding protein TRBP J Virol 1997, 71:2628-2635. 9060615
Dejardin E The alternative NF-kappaB pathway from biochemistry to biology: Pitfalls and promises for future drug development Biochem Pharmacol 2006, 72:1161-1179. 16970925
Higuchi M Tsubata C Kondo R Yoshida S Takahashi M Oie M Tanaka Y Mahieux R Matsuoka M Fujii M Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line J Virol 2007, 81:11900-11907. 17715223
Sun SC Yamaoka S Activation of NF-kappaB by HTLV-I and implications for cell transformation Oncogene 2005, 24:5952-5964. 16155602
Xiao G Cvijic ME Fong A Harhaj EW Uhlik MT Waterfield M Sun SC Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: Evidence for the involvement of IKKalpha EMBO J 2001, 20:6805-6815. 11726516
Harhaj EW Sun SC IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein J Biol Chem 1999, 274:22911-22914. 10438454
Jin DY Giordano V Kibler KV Nakano H Jeang KT Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma J Biol Chem 1999, 274:17402-17405. 10364167
Yin MJ Christerson LB Yamamoto Y Kwak YT Xu S Mercurio F Barbosa M Cobb MH Gaynor RB HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation Cell 1998, 93:875-884. 9630230
Wu X Sun SC Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK EMBO Rep 2007, 8:510-515. 17363973
Chu ZL DiDonato JA Hawiger J Ballard DW The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta J Biol Chem 1998, 273:15891-15894. 9632633
Gohda J Irisawa M Tanaka Y Sato S Ohtani K Fujisawa J Inoue J HTLV-1 Tax-induced NFkappaB activation is independent of Lys-63-linked-type polyubiquitination Biochem Biophys Res Commun 2007, 357:225-230. 17418100
Hirai H Suzuki T Fujisawa J Inoue J Yoshida M Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation Proc Natl Acad Sci U S A 1994, 91:3584-3588. 8170951
Suzuki T Hirai H Murakami T Yoshida M Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation Oncogene 1995, 10:1199-1207. 7700645
Rousset R Desbois C Bantignies F Jalinot P Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome Nature 1996, 381:328-331. 8692272
Chen ZJ Ubiquitin signalling in the NF-kappaB pathway Nat Cell Biol 2005, 7:758-765. 16056267
Perkins ND Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway Oncogene 2006, 25:6717-6730. 17072324
Kray AE Carter RS Pennington KN Gomez RJ Sanders LE Llanes JM Khan WN Ballard DW Wadzinski BE Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A J Biol Chem 2005, 280:35974-35982. 16126728
Palkowitsch L Leidner J Ghosh S Marienfeld RB Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity J Biol Chem 2008, 283:76-86. 17977820
Fu DX Kuo YL Liu BY Jeang KT Giam CZ Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A J Biol Chem 2003, 278:1487-1493. 12419799
Hong S Wang LC Gao X Kuo YL Liu B Merling R Kung HJ Shih HM Giam CZ Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax J Biol Chem 2007, 282:12119-12126. 17314097
Shembade N Harhaj NS Yamamoto M Akira S Harhaj EW The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation J Virol 2007, 81:13735-13742. 17942533
Shembade N Harhaj NS Parvatiyar K Copeland NG Jenkins NA Matesic LE Harhaj EW The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20 Nat Immunol 2008, 9:254-262. 18246070
Shembade N Harhaj NS Liebl DJ Harhaj EW Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling EMBO J 2007, 26:3910-3922. 17703191
Iha H Peloponese JM Verstrepen L Zapart G Ikeda F Smith CD Starost MF Yedavalli V Heyninck K Dikic I Beyaert R Jeang KT Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation EMBO J 2008, 27:629-641. 18239685
Heyninck K Beyaert R A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions Trends Biochem Sci 2005, 30:1-4. 15653317
Pimienta G Pascual J Canonical and alternative MAPK signaling Cell Cycle 2007, 6:2628-2632. 17957138
Yujiri T Sather S Fanger GR Johnson GL Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption Science 1998, 282:1911-1914. 9836645
Yujiri T Ware M Widmann C Oyer R Russell D Chan E Zaitsu Y Clarke P Tyler K Oka Y Fanger GR Henson P Johnson GL MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation Proc Natl Acad Sci U S A 2000, 97:7272-7277. 10852963
Delaney JR Mlodzik M TGF-beta activated kinase-1: New insights into the diverse roles of TAK1 in development and immunity Cell Cycle 2006, 5:2852-2855. 17218788
Adhikari A Xu M Chen ZJ Ubiquitin-mediated activation of TAK1 and IKK Oncogene 2007, 26:3214-3226. 17496917
Suzuki S Singhirunnusorn P Mori A Yamaoka S Kitajima I Saiki I Sakurai H Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB J Biol Chem 2007, 282:25177-25181. 17626013
Yu Q Minoda Y Yoshida R Yoshida H Iha H Kobayashi T Yoshimura A Takaesu G HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein Biochem Biophys Res Commun 2008, 365:189-194. 17986383
Xu X Heidenreich O Kitajima I McGuire K Li Q Su B Nerenberg M Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis Oncogene 1996, 13:135-142. 8700539
Jin DY Teramoto H Giam CZ Chun RF Gutkind JS Jeang KT A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha J Biol Chem 1997, 272:25816-25823. 9325311
Arnulf B Villemain A Nicot C Mordelet E Charneau P Kersual J Zermati Y Mauviel A Bazarbachi A Hermine O Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: A potential mechanism of HTLV-I leukemogenesis Blood 2002, 100:4129-4138. 12393612
Kasai T Jeang KT Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells Retrovirology 2004, 1:7. 15169569
Spain BH Bowdish KS Pacal AR Staub SF Koo D Chang CY Xie W Colicelli J Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells Mol Cell Biol 1996, 16:6698-6706. 8943324
Zhang J Kalkum M Chait BT Roeder RG The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 Mol Cell 2002, 9:611-623. 11931768
Jaffe AB Hall A Rho GTPases: Biochemistry and biology Annu Rev Cell Dev Biol 2005, 21:247-269. 16212495
Reddy TR Li X Jones Y Ellisman MH Ching GY Liem RK Wong-Staal F Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein Proc Natl Acad Sci U S A 1998, 95:702-707. 9435256
Trihn D Jeang KT Semmes OJ HTLV-I Tax and Cytokeratin: Tax-Expressing Cells Show Morphological Changes in Keratin-Containing Cytoskeletal Networks J Biomed Sci 1997, 4:47-53. 11725133
Kfoury Y Nasr R Favre-Bonvin A El Sabban M Renault N Giron ML Setterblad N Hajj HE Chiari E Mikati AG Hermine O Saib A de The H Pique C Bazarbachi A Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome Oncogene 2008, 27:1665-1676. 17891179
Nejmeddine M Barnard AL Tanaka Y Taylor GP Bangham CR Human T-lymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse J Biol Chem 2005, 280:29653-29660. 15975923
Oldham WM Hamm HE Heterotrimeric G protein activation by G-protein-coupled receptors Nat Rev Mol Cell Biol 2008, 9:60-71. 18043707
Ohshima K Pathological features of diseases associated with human T-cell leukemia virus type I Cancer Sci 2007, 98:772-778. 17388788
Fruman DA Meyers RE Cantley LC Phosphoinositide kinases Annu Rev Biochem 1998, 67:481-507. 9759495
Vanhaesebroeck B Waterfield MD Signaling by distinct classes of phosphoinositide 3-kinases Exp Cell Res 1999, 253:239-254. 10579926
Zhang X Jin B Huang C The PI3K/Akt pathway and its downstream transcriptional factors as targets for chemoprevention Curr Cancer Drug Targets 2007, 7:305-316. 17979625
Liu Y Wang Y Yamakuchi M Masuda S Tokioka T Yamaoka S Maruyama I Kitajima I Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax Oncogene 2001, 20:2514-2526. 11420661
Peloponese JM Jr. Jeang KT Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein J Biol Chem 2006, 281:8927-8938. 16436385
Paez J Sellers WR PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling Cancer Treat Res 2003, 115:145-167. 12613196
Yu J Wjasow C Backer JM Regulation of the p85/p110alpha phosphatidylinositol 3′-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains J Biol Chem 1998, 273:30199-30203. 9804776
Yu J Zhang Y McIlroy J Rordorf-Nikolic T Orr GA Backer JM Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit Mol Cell Biol 1998, 18:1379-1387. 9488453
Ueki K Fruman DA Brachmann SM Tseng YH Cantley LC Kahn CR Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival Mol Cell Biol 2002, 22:965-977. 11784871
Mori N Fujii M Iwai K Ikeda S Yamasaki Y Hata T Yamada Y Tanaka Y Tomonaga M Yamamoto N Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells Blood 2000, 95:3915-3921. 10845928
Iwai K Mori N Oie M Yamamoto N Fujii M Human T-cell leukemia virus type 1 tax protein activates transcription through AP-1 site by inducing DNA binding activity in T cells Virology 2001, 279:38-46. 11145887
Pennison M Pasche B Targeting transforming growth factor-beta signaling Curr Opin Oncol 2007, 19:579-585. 17906455
Schmierer B Hill CS TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility Nat Rev Mol Cell Biol 2007, 8:970-982. 18000526
Kim SJ Kehrl JH Burton J Tendler CL Jeang KT Danielpour D Thevenin C Kim KY Sporn MB Roberts AB Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: A potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia J Exp Med 1990, 172:121-129. 2358774
Nagai M Ijichi S Hall WW Osame M Differential effect of TGF-beta 1 on the in vitro activation of HTLV-I and the proliferative response of CD8+ T lymphocytes in patients with HTLV-I-associated myelopathy (HAM/TSP) Clin Immunol Immunopathol 1995, 77:324-331. 7586743
Moriuchi M Moriuchi H Transforming growth factor-beta enhances human T-cell leukemia virus type I infection J Med Virol 2002, 67:427-430. 12116037
Jones KS Akel S Petrow-Sadowski C Huang Y Bertolette DC Ruscetti FW Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta J Immunol 2005, 174:4262-4270. 15778389
Lee DK Kim BC Brady JN Jeang KT Kim SJ Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element J Biol Chem 2002, 277:33766-33775. 12097320
Mori N Morishita M Tsukazaki T Giam CZ Kumatori A Tanaka Y Yamamoto N Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300 Blood 2001, 97:2137-2144. 11264182
Defilippi P Di Stefano P Cabodi S p130Cas: A versatile scaffold in signaling networks Trends Cell Biol 2006, 16:257-263. 16581250
Iwata S Souta-Kuribara A Yamakawa A Sasaki T Shimizu T Hosono O Kawasaki H Tanaka H Dang NH Watanabe T Arima N Morimoto C HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L) Oncogene 2005, 24:1262-1271. 15592516
Minegishi M Tachibana K Sato T Iwata S Nojima Y Morimoto C Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes J Exp Med 1996, 184:1365-1375. 8879209
Miyake-Nishijima R Iwata S Saijo S Kobayashi H Kobayashi S Souta-Kuribara A Hosono O Kawasaki H Tanaka H Ikeda E Okada Y Iwakura Y Morimoto C Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans Arthritis Rheum 2003, 48:1890-1900. 12847683
Harper JV Brooks G The mammalian cell cycle: An overview Methods Mol Biol 2005, 296:113-153. 15576929
Jeang KT Giam CZ Majone F Aboud M Life, death, and tax: Role of HTLV-I oncoprotein in genetic instability and cellular transformation J Biol Chem 2004, 279:31991-31994. 15090550
Marriott SJ Semmes OJ Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response Oncogene 2005, 24:5986-5995. 16155605
Haller K Wu Y Derow E Schmitt I Jeang KT Grassmann R Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein Mol Cell Biol 2002, 22:3327-3338. 11971966
Haller K Ruckes T Schmitt I Saul D Derow E Grassmann R Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells AIDS Res Hum Retroviruses 2000, 16:1683-1688. 11080810
Fraedrich K Muller B Grassmann R The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix Retrovirology 2005, 2:54. 16164752
Neuveut C Low KG Maldarelli F Schmitt I Majone F Grassmann R Jeang KT Human T-cell leukemia virus type 1 Tax and cell cycle progression: Role of cyclin D-cdk and p110Rb Mol Cell Biol 1998, 18:3620-3632. 9584203
Suzuki T Kitao S Matsushime H Yoshida M HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4 EMBO J 1996, 15:1607-1614. 8612584
Suzuki T Yoshida M HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16Ink4a and counteracts its inhibitory activity to CDK4 Leukemia 1997, 11(Suppl 3):14-16. 9209282
Low KG Dorner LF Fernando DB Grossman J Jeang KT Comb MJ Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a J Virol 1997, 71:1956-1962. 9032327
Suzuki T Narita T Uchida-Toita M Yoshida M Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms Virology 1999, 259:384-391. 10388662
Kehn K Fuente CL Strouss K Berro R Jiang H Brady J Mahieux R Pumfery A Bottazzi ME Kashanchi F The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation Oncogene 2005, 24:525-540. 15580311
Lemoine FJ Marriott SJ Accelerated G(1) phase progression induced by the human T cell leukemia virus type I (HTLV-I) Tax oncoprotein J Biol Chem 2001, 276:31851-31857. 11435441
Asquith B Zhang Y Mosley AJ de Lara CM Wallace DL Worth A Kaftantzi L Meekings K Griffin GE Tanaka Y Tough DF Beverley PC Taylor GP Macallan DC Bangham CR In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection Proc Natl Acad Sci U S A 2007, 104:8035-8040. 17483473
Zhou BB Elledge SJ The DNA damage response: Putting checkpoints in perspective Nature 2000, 408:433-439. 11100718
Zhou BB Anderson HJ Roberge M Targeting DNA checkpoint kinases in cancer therapy Cancer Biol Ther 2003, 2:S16-S22. 14508077
Niida H Nakanishi M DNA damage checkpoints in mammals Mutagenesis 2006, 21:3-9. 16314342
Marriott SJ Lemoine FJ Jeang KT Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells J Biomed Sci 2002, 9;292-298. 12145525
Majone F Jeang KT Clastogenic effect of the human T-cell leukemia virus type I Tax oncoprotein correlates with unstabilized DNA breaks J Biol Chem 2000, 275:32906-32910. 10969065
Majone F Luisetto R Zamboni D Iwanaga Y Jeang KT Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells Retrovirology 2005, 2:45. 16014171
Branzei D Foiani M Regulation of DNA repair throughout the cell cycle Nat Rev Mol Cell Biol 2008, 9:297-308. 18285803
Haoudi A Daniels RC Wong E Kupfer G Semmes OJ Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response J Biol Chem 2003, 278:37736-37744. 12842897
Park HU Jeong JH Chung JH Brady JN Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1 Oncogene 2004, 23:4966-4974. 15107832
Park HU Jeong SJ Jeong JH Chung JH Brady JN Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2 Oncogene 2006, 25:438-447. 16158050
Gupta SK Guo X Durkin SS Fryrear KF Ward MD Semmes OJ Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2 J Biol Chem 2007, 282:29431-29440. 17698850
Liang MH Geisbert T Yao Y Hinrichs SH Giam CZ Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis J Virol 2002, 76:4022-4033. 11907241
Li J Stern DF DNA damage regulates Chk2 association with chromatin J Biol Chem 2005, 280:37948-37956. 16150728
Nigg EA Centrosome aberrations: Cause or consequence of cancer progression? Nat Rev Cancer 2002, 2:815-825. 12415252
Nitta T Kanai M Sugihara E Tanaka M Sun B Nagasawa T Sonoda S Saya H Miwa M Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells Cancer Sci 2006, 97:836-841. 16805820
Kramer A Neben K Ho AD Centrosome replication, genomic instability and cancer Leukemia 2002, 16:767-775. 11986936
Fukasawa K Oncogenes and tumour suppressors take on centrosomes Nat Rev Cancer 2007, 7:911-924. 18004399
Peloponese JM Jr. Haller K Miyazato A Jeang KT Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein Proc Natl Acad Sci U S A 2005, 102:18974-18979. 16365316
Ching YP Chan SF Jeang KT Jin DY The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication Nat Cell Biol 2006, 8:717-724. 16767081
Guarguaglini G Renzi L D'Ottavio F Di Fiore B Casenghi M Cundari E Lavia P Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo Cell Growth Differ 2000, 11:455-465. 10965850
Di Fiore B Ciciarello M Mangiacasale R Palena A Tassin AM Cundari E Lavia P Mammalian RanBP1 regulates centrosome cohesion during mitosis J Cell Sci 2003, 116:3399-3411. 12840069
Wong C Stearns T Centrosome number is controlled by a centrosome-intrinsic block to reduplication Nat Cell Biol 2003, 5:539-544. 12766773
Malmanche N Maia A Sunkel CE The spindle assembly checkpoint: Preventing chromosome mis-segregation during mitosis and meiosis FEBS Lett 2006, 580:2888-2895. 16631173
Bharadwaj R Qi W Yu H Identification of two novel components of the human NDC80 kinetochore complex J Biol Chem 2004, 279:13076-13085. 14699129
Yu H Cdc20: A WD40 activator for a cell cycle degradation machine Mol Cell 2007, 27:3-16. 17612486
Kasai T Iwanaga Y Iha H Jeang KT Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors J Biol Chem 2002, 277:5187-5193. 11729202
Jin DY Spencer F Jeang KT Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 Cell 1998, 93:81-91. 9546394
Yu H Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model J Cell Biol 2006, 173:153-157. 16636141
Liu B Hong S Tang Z Yu H Giam CZ HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule Proc Natl Acad Sci U S A 2005, 102:63-68. 15623561
Liu B Liang MH Kuo YL Liao W Boros I Kleinberger T Blancato J Giam CZ Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability Mol Cell Biol 2003, 23:5269-5281. 12861013
Kuo YL Giam CZ Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence EMBO J 2006, 25:1741-1752. 16601696
Merling R Chen C Hong S Zhang L Liu M Kuo YL Giam CZ HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex Retrovirology 2007, 4:35. 17535428
Sheleg SV Peloponese JM Chi YH Li Y Eckhaus M Jeang KT Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax J Virol 2007, 81:7894-7901. 17507465
Craven SE Bredt DS PDZ proteins organize synaptic signaling pathways Cell 1998, 93:495-498. 9604925
Fanning AS Anderson JM Protein modules as organizers of membrane structure Curr Opin Cell Biol 1999, 11:432-439. 10449334
Fanning AS Anderson JM PDZ domains: Fundamental building blocks in the organization of protein complexes at the plasma membrane J Clin Invest 1999, 103:767-772. 10079096
Rousset R Fabre S Desbois C Bantignies F Jalinot P The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins Oncogene 1998, 16:643-654. 9482110
Wilson KC Center DM Cruikshank WW Zhang Y Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein Virology 2003, 306:60-67. 12620798
Lee SS Weiss RS Javier RT Binding of human virus oncoproteins to hDlg/ SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein Proc Natl Acad Sci U S A 1997, 94:6670-6675. 9192623
Suzuki T Ohsugi Y Uchida-Toita M Akiyama T Yoshida M Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control Oncogene 1999, 18:5967-5972. 10557085
Reynaud C Fabre S Jalinot P The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element J Biol Chem 2000, 275:33962-33968. 10940294
Ohashi M Sakurai M Higuchi M Mori N Fukushi M Oie M Coffey RJ Yoshiura K Tanaka Y Uchiyama M Hatanaka M Fujii M Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3 Virology 2004, 320:52-62. 15003862
Cheng H Cenciarelli C Shao Z Vidal M Parks WP Pagano M Cheng-Mayer C Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70 Curr Biol 2001, 11:1771-1775. 11719219
Arpin-Andre C Mesnard JM The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells J Biol Chem 2007, 282:33132-33141. 17855372
Hirata A Higuchi M Niinuma A Ohashi M Fukushi M Oie M Akiyama T Tanaka Y Gejyo F Fujii M PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line Virology 2004, 318:327-336. 14972558
Ishidate T Matsumine A Toyoshima K Akiyama T The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase Oncogene 2000, 19:365-372. 10656683
Senda T Shimomura A Iizuka-Kogo A Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene Anat Sci Int 2005, 80:121-131. 16158975
Krummel MF Macara I Maintenance and modulation of T cell polarity Nat Immunol 2006, 7:1143-1149. 17053799
Ishioka K Higuchi M Takahashi M Yoshida S Oie M Tanaka Y Takahashi S Xie L Green PL Fujii M Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein Retrovirology 2006, 3:71. 17042961
Tsubata C Higuchi M Takahashi M Oie M Tanaka Y Gejyo F Fujii M PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line Retrovirology 2005, 2:46. 16042787
Xie L Yamamoto B Haoudi A Semmes OJ Green PL PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo Blood 2006, 107:1980-1988. 16263794
Endo K Hirata A Iwai K Sakurai M Fukushi M Oie M Higuchi M Hall WW Gejyo F Fujii M Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax J Virol 2002, 76:2648-2653. 11861831
Smith MR Greene WC Characterization of a novel nuclear localization signal in the HTLV-I tax transactivator protein Virology 1992, 187:316-320. 1736534
Burton M Upadhyaya CD Maier B Hope TJ Semmes OJ Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets J Virol 2000, 74:2351-2364. 10666266
Alefantis T Barmak K Harhaj EW Grant C Wigdahl B Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax J Biol Chem 2003, 278:21814-21822. 12670929
Alefantis T Mostoller K Jain P Harhaj E Grant C Wigdahl B Secretion of the human T cell leukemia virus type I transactivator protein tax J Biol Chem 2005, 280:17353-17362. 15659397
Marriott SJ Lindholm PF Reid RL Brady JN Soluble HTLV-I Tax1 protein stimulates proliferation of human peripheral blood lymphocytes New Biol 1991, 3:678-686. 1751450
Jain P Mostoller K Flaig KE Ahuja J Lepoutre V Alefantis T Khan ZK Wigdahl B Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein J Biol Chem 2007, 282:34581-34593. 17897946
Tsuji T Sheehy N Gautier VW Hayakawa H Sawa H Hall WW The nuclear import of the human T lymphotropic virus type I (HTLV-1) tax protein is carrier- and energy-independent J Biol Chem 2007, 282:13875-13883. 17344183
Gatza ML Marriott SJ Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanism J Virol 2006, 80:6657-6668. 16775353
Gatza ML Dayaram T Marriott SJ Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export Retrovirology 2007, 4:95. 18081936
Alefantis T Flaig KE Wigdahl B Jain P Interaction of HTLV-1 Tax protein with calreticulin: Implications for Tax nuclear export and secretion Biomed Pharmacother 2007, 61:194-200. 17395420
Fried H Kutay U Nucleocytoplasmic transport: Taking an inventory Cell Mol Life Sci 2003, 60:1659-1688. 14504656
Terry LJ Shows EB Wente SR Crossing the nuclear envelope: Hierarchical regulation of nucleocytoplasmic transport Science 2007, 318:1412-1416. 18048681
Hutten S Kehlenbach RH CRM1-mediated nuclear export: To the pore and beyond Trends Cell Biol 2007, 17:193-201. 17317185
Alefantis T Jain P Ahuja J Mostoller K Wigdahl B HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic disease J Biomed Sci 2005, 12:961-974. 16228291
Holaska JM Black BE Love DC Hanover JA Leszyk J Paschal BM Calreticulin Is a receptor for nuclear export J Cell Biol 2001, 152:127-140. 11149926
Goren I Semmes OJ Jeang KT Moelling K The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein J Virol 1995, 69:5806-5811. 7637025
Twizere JC Springael JY Boxus M Burny A Dequiedt F Dewulf JF Duchateau J Portetelle D Urbain P Van Lint C Green PL Mahieux R Parmentier M Willems L Kettmann R Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling Blood 2007, 109:1051-1060. 16990599
Xiao G Harhaj EW Sun SC Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK J Biol Chem 2000, 275:34060-34067. 10906125
Basbous J Bazarbachi A Granier C Devaux C Mesnard JM The central region of human T-cell leukemia virus type 1 Tax protein contains distinct domains involved in subunit dimerization J Virol 2003, 77:13028-13035. 14645559
Chun AC Zhou Y Wong CM Kung HF Jeang KT Jin DY Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors AIDS Res Hum Retroviruses 2000, 16:1689-1694. 11080811
Semmes OJ Jeang KT Definition of a minimal activation domain in human T-cell leukemia virus type I Tax J Virol 1995, 69:1827-1833. 7853523
Asquith B Bangham CR How does HTLV-I persist despite a strong cell-mediated immune response? Trends Immunol 2008, 29:4-11. 18042431
Kaul R Verma SC Robertson ES Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA Virology 2007, 364:317-329. 17434559
Berk AJ Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus Oncogene 2005, 24:7673-7685. 16299528
Gallimore PH Turnell AS Adenovirus E1A: Remodelling the host cell, a life or death experience Oncogene 2001, 20:7824-7835. 11753665
Bex F McDowall A Burny A Gaynor R The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins J Virol 1997, 71:3484-3497. 9094620
Radivojac P Iakoucheva LM Oldfield CJ Obradovic Z Uversky VN Dunker AK Intrinsic disorder and functional proteomics Biophys J 2007, 92:1439-1456. 17158572
Dunker AK Cortese MS Romero P Iakoucheva LM Uversky VN Flexible nets. The roles of intrinsic disorder in protein interaction networks FEBS J 2005, 272:5129-5148. 16218947
Kim PM Sboner A Xia Y Gerstein M The role of disorder in interaction networks: A structural analysis Mol Syst Biol 2008, 4:179. 18364713
Han JD Bertin N Hao T Goldberg DS Berriz GF Zhang LV Dupuy D Walhout AJ Cusick ME Roth FP Vidal M Evidence for dynamically organized modularity in the yeast protein-protein interaction network Nature 2004, 430:88-93. 15190252
Uversky VN Roman A Oldfield CJ Dunker AK Protein intrinsic disorder and human papillomaviruses: Increased amount of disorder in E6 and E7 oncoproteins from high risk HPVs J Proteome Res 2006, 5:1829-1842. 16889404
Durkin SS Ward MD Fryrear KA Semmes OJ Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein J Biol Chem 2006, 281:31705-31712. 16923801
Kashanchi F Brady JN Transcriptional and post-transcriptional gene regulation of HTLV-1 Oncogene 2005, 24:5938-5951. 16155601
Beraud C Sun SC Ganchi P Ballard DW Greene WC Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: Implications for viral latency Mol Cell Biol 1994, 14:1374-1382. 8289813
Yang X Wang JS Han H [Interaction between HTLV-1 transcription activator tax and Taxreb107] Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2002, 34:231-235. 12007002