Cell Cycle Proteins/genetics/metabolism; Gene Products, tax/chemistry/genetics/metabolism; HTLV-I Infections/metabolism/physiopathology/virology; Host-Pathogen Interactions; Human T-lymphotropic virus 1/chemistry/enzymology/genetics; Humans; Nuclear Pore Complex Proteins/genetics/metabolism; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Transcription Factors/genetics/metabolism; Transcriptional Activation
[en] The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.