Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.

Florins, Arnaud-Francois; Boxus, Mathieu; Vandermeers, Fabian; Verlaeten, Olivier; Bouzar, Amel; Defoiche, Julien; Hubaux, Roland; Burny, Arsène; Kettmann, Richard; Willems, Luc

doi:10.1016/j.vetimm.2008.04.007

Article (Scientific journals)

Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.

Florins, Arnaud-Francois; Boxus, Mathieu; Vandermeers, Fabian et al.

2008 • In Veterinary Immunology and Immunopathology, 125 (1-2), p. 1-7

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/10427

DOI
10.1016/j.vetimm.2008.04.007

PubMed
18513803

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Keywords :

Animals; B-Lymphocytes/immunology/pathology; Cattle; Enzootic Bovine Leukosis/genetics/immunology/pathology/virology; Genes, p53; Leukemia Virus, Bovine/immunology; Lymphocyte Activation; Lymphoid Tissue/immunology/pathology; Sheep; Sheep Diseases/genetics/immunology/pathology/virology

Abstract :

[en] Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Florins, Arnaud-Francois ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Boxus, Mathieu ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Vandermeers, Fabian ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Verlaeten, Olivier

Bouzar, Amel ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Defoiche, Julien

Hubaux, Roland

Burny, Arsène ; Université de Liège - ULiège > Agro Biotech Gembloux

Kettmann, Richard ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Willems, Luc ; Université de Liège - ULiège > GIGA-Research

Language :

English

Title :

Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.

Publication date :

2008

Journal title :

Veterinary Immunology and Immunopathology

ISSN :

0165-2427

eISSN :

1873-2534

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

125

Issue :

1-2

Pages :

1-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 April 2009

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