Article (Scientific journals)
Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV
Rodriguez, Sabrina; Florins, Arnaud-Francois; Gillet, Nicolas et al.
2011In Viruses, 3 (7), p. 1210-1248
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Keywords :
BLV; therapeutics; vaccines; epigenetic; eradication; control
Abstract :
[en] Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.
Disciplines :
Oncology
Author, co-author :
Rodriguez, Sabrina ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Florins, Arnaud-Francois ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Gillet, Nicolas ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
De Brogniez, Alix ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Sanchez-Alcaraz, Maria-Thérésa ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Boxus, Mathieu ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Boulanger, Fanny
Gutiérrez, Gerónimo
Trono, Karina
Alvarez, Irene
Vagnoni, Lucas
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Language :
English
Title :
Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV
Publication date :
19 July 2011
Journal title :
Viruses
eISSN :
1999-4915
Publisher :
MDPI, Basel, Switzerland
Special issue title :
Recent Developments in HTLV Research
Volume :
3
Issue :
7
Pages :
1210-1248
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 November 2011

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