Reference : Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)sily...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]propanamine-based prosthetic groups
Balentova, Eva [ > > ]
Collet, Charlotte [ > > ]
Lamande-Langle, Sandrine [ > > ]
Chretien, Françoise [ > > ]
Thonon, David mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Aerts, Joël mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse >]
Chapleur, Yves [ > > ]
Journal of Fluorine Chemistry
Elsevier Science
Yes (verified by ORBi)
[en] Two new silicon-based prosthetic groups, derived from 3-[ethoxybis(1-methylethyl)silyl]propanamine, have been prepd.
in good yields. These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly-
Gly) either through a classical amide bond formation or through "click chem." via the Huisgen cycloaddn. The
radiolabeling with fluorine-18 by substitution of the ethoxy group at silicon has been carried out with success in 51-54%
decay cor. radiochem. yields. Radiolabeled peptides were easily prepd. by direct 18F-fluorination of the silicon-bearing
tripeptide or by coupling the peptide with a radiolabeled silicon-based prosthetic group. Their stabilities in physiol.
medium were studied and proved poor.

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