[en] Two new silicon-based prosthetic groups, derived from 3-[ethoxybis(1-methylethyl)silyl]propanamine, have been prepd.
in good yields. These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly-
Gly) either through a classical amide bond formation or through "click chem." via the Huisgen cycloaddn. The
radiolabeling with fluorine-18 by substitution of the ethoxy group at silicon has been carried out with success in 51-54%
decay cor. radiochem. yields. Radiolabeled peptides were easily prepd. by direct 18F-fluorination of the silicon-bearing
tripeptide or by coupling the peptide with a radiolabeled silicon-based prosthetic group. Their stabilities in physiol.
medium were studied and proved poor.
Disciplines :
Chemistry
Author, co-author :
Balentova, Eva
Collet, Charlotte
Lamande-Langle, Sandrine
Chretien, Françoise
Thonon, David ; Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, Joël ; Université de Liège - ULiège > Centre de recherches du cyclotron
Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse
Chapleur, Yves
Language :
English
Title :
Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]propanamine-based prosthetic groups
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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