Article (Scientific journals)
Imaging apolipoprotein AI in vivo
Sriram, Renuka; Lagerstedt, Jens; Petrlova, Jitka et al.
2011In NMR in Biomedicine, 24 (7), p. 916-924
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Abstract :
[en] Coronary disease risk increases inversely with high-d. lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a tech. challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the major protein of HDL. The contrast agent targets both liver and kidney, the sites of HDL catabolism, whereas the std. MRI contrast agent, gadolinium-diethylenetriaminepentaacetic acidbismethylamide (GdDTPA-BMA, gadodiamide), enhances only the kidney image. Using a modified apolipoprotein AI to create an HDL contrast agent provides a new approach to investigate HDL biodistribution, metab. and regulation in vivo.
Disciplines :
Chemistry
Author, co-author :
Sriram, Renuka
Lagerstedt, Jens
Petrlova, Jitka
Samardzic, Haris
Kreutzer, Ulrike
Xie, Hongtao
Kaysen, George
Desreux, Jean-François ;  Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Thonon, David ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Jacques, Vincent
Van Loan, M.
Rutledge, J. C.
Oda, M. N.
Voss, John
Jue, T.
More authors (5 more) Less
Language :
English
Title :
Imaging apolipoprotein AI in vivo
Publication date :
2011
Journal title :
NMR in Biomedicine
ISSN :
0952-3480
eISSN :
1099-1492
Publisher :
Wiley, Chichester, United Kingdom
Volume :
24
Issue :
7
Pages :
916-924
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 November 2011

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